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    Fnip1 folliculin interacting protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100362347, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Fnip1provided by RGD
    Official Full Name
    folliculin interacting protein 1provided by RGD
    Primary source
    RGD:2318339
    See related
    EnsemblRapid:ENSRNOG00000009104 AllianceGenome:RGD:2318339
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including ATPase inhibitor activity; enzyme activator activity; and protein-folding chaperone binding activity. Predicted to be involved in several processes, including negative regulation of lysosome organization; regulation of TOR signaling; and regulation of primary metabolic process. Predicted to act upstream of or within with a positive effect on negative regulation of cell population proliferation. Predicted to be located in cytosol and lysosomal membrane. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human FNIP1 (folliculin interacting protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 244.6), Heart (RPKM 199.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fnip1 in Genome Data Viewer
    Location:
    10q22
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (39068432..39151552)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (38567728..38650824)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (39786687..39870188)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120095099 Neighboring gene acyl-CoA synthetase long-chain family member 6 Neighboring gene meiotic kinetochore factor Neighboring gene U6 spliceosomal RNA Neighboring gene Rap guanine nucleotide exchange factor 6 Neighboring gene uncharacterized LOC134480793 Neighboring gene CDC42 small effector 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Disruption of Fnip1 reveals a metabolic checkpoint controlling B lymphocyte development. Park H, et al. Immunity, 2012 May 25. PMID 22608497, Free PMC Article
    2. GATOR1-dependent recruitment of FLCN-FNIP to lysosomes coordinates Rag GTPase heterodimer nucleotide status in response to amino acids. Meng J, et al. J Cell Biol, 2018 Aug 6. PMID 29848618, Free PMC Article
    3. Amino Acid Sensing by mTORC1: Intracellular Transporters Mark the Spot. Goberdhan DC, et al. Cell Metab, 2016 Apr 12. PMID 27076075, Free PMC Article
    4. Crystal structure of folliculin reveals a hidDENN function in genetically inherited renal cancer. Nookala RK, et al. Open Biol, 2012 Aug. PMID 22977732, Free PMC Article
    5. Folliculin-interacting proteins Fnip1 and Fnip2 play critical roles in kidney tumor suppression in cooperation with Flcn. Hasumi H, et al. Proc Natl Acad Sci U S A, 2015 Mar 31. PMID 25775561, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATPase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATPase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables enzyme activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-folding chaperone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-folding chaperone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of B cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in B cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of TOR signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cellular response to starvation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to starvation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within immature B cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in immature B cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within negative regulation of TOR signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of TOR signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within_positive_effect negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cysteine-type endopeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of lysosome organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within positive regulation of B cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of B cell apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of TOR signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of TORC1 signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of pro-B cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of pro-B cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    folliculin-interacting protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271163.2 → NP_001258092.2  folliculin-interacting protein 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A8I6A2V5, A6HEH8
      Related
      ENSRNOP00000086762.1, ENSRNOT00000115556.2
      Conserved Domains (3) summary
      pfam14636
      Location:41 → 155
      FNIP_N; Folliculin-interacting protein N-terminus
      pfam14637
      Location:316 → 548
      FNIP_M; Folliculin-interacting protein middle domain
      pfam14638
      Location:975 → 1161
      FNIP_C; Folliculin-interacting protein C-terminus

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      39068432..39151552
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039084999.2 → XP_038940927.1  folliculin-interacting protein 1 isoform X2

      UniProtKB/TrEMBL
      F1LUD4
      Related
      ENSRNOP00000101969.1, ENSRNOT00000130900.1
      Conserved Domains (3) summary
      pfam14636
      Location:41 → 155
      FNIP_N; Folliculin-interacting protein N-terminus
      pfam14637
      Location:288 → 520
      FNIP_M; Folliculin-interacting protein middle domain
      pfam14638
      Location:947 → 1133
      FNIP_C; Folliculin-interacting protein C-terminus

    2. XM_039084998.2 → XP_038940926.1  folliculin-interacting protein 1 isoform X1

      Related
      ENSRNOP00000012671.8, ENSRNOT00000012671.8
      Conserved Domains (3) summary
      pfam14636
      Location:20 → 134
      FNIP_N; Folliculin-interacting protein N-terminus
      pfam14637
      Location:295 → 527
      FNIP_M; Folliculin-interacting protein middle domain
      pfam14638
      Location:954 → 1140
      FNIP_C; Folliculin-interacting protein C-terminus
    Nucleotide Protein Strain
    Heading Accession and Version

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