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    Selenot selenoprotein T [ Rattus norvegicus (Norway rat) ]

    Gene ID: 365802, updated on 4-Jan-2025

    Summary

    Official Symbol
    Selenotprovided by RGD
    Official Full Name
    selenoprotein Tprovided by RGD
    Primary source
    RGD:1359128
    See related
    EnsemblRapid:ENSRNOG00000013507 AllianceGenome:RGD:1359128
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    This gene encodes a selenoprotein, containing a selenocysteine (Sec) residue at the active site. Sec is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is localized in the endoplasmic reticulum. It belongs to the SelWTH family that possesses a thioredoxin-like fold and a conserved CxxU (C is cysteine, U is Sec) motif found in several redox active proteins. Studies in rat indicate a role for this gene in the regulation of calcium homeostasis and smooth muscle contraction. High induction of this gene is also associated with ontogenetic and regenerative processes in nervous, endocrine, and metabolic tissues. A pseudogene of this locus has been identified on chromosome 4. [provided by RefSeq, Aug 2017]
    Expression
    Biased expression in Kidney (RPKM 542.3), Muscle (RPKM 521.5) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Selenot in Genome Data Viewer
    Location:
    2q26
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (144954324..144971375)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (142804387..142821438)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (148765412..148781080)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene stress-associated endoplasmic reticulum protein 1 Neighboring gene eukaryotic translation initiation factor 2A Neighboring gene glutamate-rich 6 Neighboring gene uncharacterized LOC134485621 Neighboring gene siah E3 ubiquitin protein ligase 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in cell redox homeostasis  
    involved_in cell redox homeostasis  
    involved_in cell redox homeostasis  
    involved_in cell redox homeostasis  
    involved_in cellular oxidant detoxification PubMed 
    acts_upstream_of_or_within glucose homeostasis  
    involved_in glucose homeostasis  
    involved_in insulin secretion involved in cellular response to glucose stimulus  
    acts_upstream_of_or_within insulin secretion involved in cellular response to glucose stimulus  
    involved_in insulin secretion involved in cellular response to glucose stimulus  
    involved_in pancreas development  
    acts_upstream_of_or_within pancreas development  
    involved_in pancreas development  
    involved_in positive regulation of cytosolic calcium ion concentration PubMed 
    involved_in positive regulation of growth hormone secretion PubMed 
    acts_upstream_of_or_within response to glucose  
    involved_in response to glucose  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum  
    located_in endoplasmic reticulum  
    is_active_in endoplasmic reticulum membrane  
    located_in endoplasmic reticulum membrane PubMed 

    General protein information

    Preferred Names
    thioredoxin reductase-like selenoprotein T
    Names
    thioredoxin reductase-like enzyme
    NP_001014275.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014253.3NP_001014275.2  thioredoxin reductase-like selenoprotein T precursor

      See identical proteins and their annotated locations for NP_001014275.2

      Status: REVIEWED

      Source sequence(s)
      FM042340, FM061880, JAXUCZ010000002
      UniProtKB/Swiss-Prot
      Q1H5H1
      UniProtKB/TrEMBL
      F8WFN1
      Related
      ENSRNOP00000018248.6, ENSRNOT00000018248.8
      Conserved Domains (1) summary
      TIGR02174
      Location:41179
      CXXU_selWTH; selT/selW/selH selenoprotein domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      144954324..144971375
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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