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    Pdzd11 PDZ domain containing 11 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 302422, updated on 27-Dec-2024

    Summary

    Official Symbol
    Pdzd11provided by RGD
    Official Full Name
    PDZ domain containing 11provided by RGD
    Primary source
    RGD:1560007
    See related
    AllianceGenome:RGD:1560007
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1560007
    Summary
    Predicted to enable protein-macromolecule adaptor activity. Predicted to be involved in several processes, including pore complex assembly; regulation of synaptic assembly at neuromuscular junction; and synaptic vesicle transport. Predicted to be located in cytosol. Predicted to be part of pore complex. Predicted to be active in basolateral plasma membrane and cell-cell junction. Orthologous to human PDZD11 (PDZ domain containing 11). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 143.2), Lung (RPKM 141.4) and 9 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Pdzd11 in Genome Data Viewer
    Location:
    Xq22
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (69758765..69761811, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (65718689..65721742, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (70458601..70461635, complement)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene acyl-CoA wax alcohol acyltransferase 1 Neighboring gene pyrimidinergic receptor P2Y4 Neighboring gene arrestin 3 Neighboring gene uncharacterized LOC120099344 Neighboring gene kinesin family member 4A Neighboring gene transfer RNA phenylalanine (anticodon GAA) 8

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Clone Names

    • MGC188839

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein-macromolecule adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in neurotransmitter secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in pore complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in pore complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of synaptic assembly at neuromuscular junction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in synaptic vesicle transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in basolateral plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cell-cell junction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    part_of pore complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    PDZ domain-containing protein 11

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106945.2NP_001100415.1  PDZ domain-containing protein 11 isoform 1

      See identical proteins and their annotated locations for NP_001100415.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A6IQ85
      Conserved Domains (1) summary
      cd00992
      Location:45125
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    2. NM_001433984.1NP_001420913.1  PDZ domain-containing protein 11 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A6IQ85
    3. NM_001433985.1NP_001420914.1  PDZ domain-containing protein 11 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
    4. NM_001433986.1NP_001420915.1  PDZ domain-containing protein 11 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      B5DEN7

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      69758765..69761811 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006257070.5XP_006257132.1  PDZ domain-containing protein 11 isoform X5

      Conserved Domains (1) summary
      cd00992
      Location:3097
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    2. XM_006257068.5XP_006257130.1  PDZ domain-containing protein 11 isoform X3

      Conserved Domains (1) summary
      cd00992
      Location:45125
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    3. XM_063279895.1XP_063135965.1  PDZ domain-containing protein 11 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A9Z8
    4. XM_039099594.2XP_038955522.1  PDZ domain-containing protein 11 isoform X2

      Conserved Domains (1) summary
      cd00992
      Location:45130
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    5. XM_063279897.1XP_063135967.1  PDZ domain-containing protein 11 isoform X4

    6. XM_039099595.2XP_038955523.1  PDZ domain-containing protein 11 isoform X2

      Conserved Domains (1) summary
      cd00992
      Location:45130
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    7. XM_063279899.1XP_063135969.1  PDZ domain-containing protein 11 isoform X5

      UniProtKB/TrEMBL
      B5DEN7
    8. XM_063279898.1XP_063135968.1  PDZ domain-containing protein 11 isoform X4

    9. XM_063279896.1XP_063135966.1  PDZ domain-containing protein 11 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A9Z8