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    Srrt serrate, RNA effector molecule [ Rattus norvegicus (Norway rat) ]

    Gene ID: 686980, updated on 27-Dec-2024

    Summary

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    Symbol
    Srrtprovided by RGD
    Full Name
    serrate, RNA effector moleculeprovided by RGD
    Primary source
    RGD:1591241
    See related
    EnsemblRapid:ENSRNOG00000048277 AllianceGenome:RGD:1591241
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    AABR07035787.1
    Summary
    Predicted to enable DNA binding activity; mRNA cap binding complex binding activity; and protein-macromolecule adaptor activity. Predicted to be involved in neuronal stem cell population maintenance; positive regulation of neurogenesis; and regulation of gene expression. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be part of ribonucleoprotein complex. Predicted to be active in nuclear body. Orthologous to human SRRT (serrate, RNA effector molecule). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 265.5), Spleen (RPKM 189.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Srrt in Genome Data Viewer
    Location:
    12q12
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (25027883..25042847)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (19392578..19406098)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (22457898..22471090)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 12, member 9 Neighboring gene thyroid hormone receptor interactor 6 Neighboring gene UFM1-specific peptidase 1 Neighboring gene acetylcholinesterase Neighboring gene uncharacterized LOC120095907

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Ars2 maintains neural stem-cell identity through direct transcriptional activation of Sox2. Andreu-Agullo C, et al. Nature, 2011 Dec 25. PMID 22198669, Free PMC Article
    2. Ars2 links the nuclear cap-binding complex to RNA interference and cell proliferation. Gruber JJ, et al. Cell, 2009 Jul 23. PMID 19632182, Free PMC Article
    3. The nuclear cap-binding complex interacts with the U4/U6·U5 tri-snRNP and promotes spliceosome assembly in mammalian cells. Pabis M, et al. RNA, 2013 Aug. PMID 23793891, Free PMC Article
    4. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
    5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA cap binding complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-macromolecule adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neuronal stem cell population maintenance ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of neurogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in primary miRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in primary miRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nuclear body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    serrate RNA effector molecule homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427441.1 → NP_001414370.1  serrate RNA effector molecule homolog

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      Related
      ENSRNOP00000094934.2, ENSRNOT00000113858.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      25027883..25042847
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039090063.2 → XP_038945991.1  serrate RNA effector molecule homolog isoform X5

      UniProtKB/TrEMBL
      A0A8I6AM26
      Conserved Domains (2) summary
      pfam04959
      Location:645 → 842
      ARS2; Arsenite-resistance protein 2
      pfam12066
      Location:153 → 262
      DUF3546; Domain of unknown function (DUF3546)

    2. XM_039090059.2 → XP_038945987.1  serrate RNA effector molecule homolog isoform X1

      Conserved Domains (2) summary
      pfam04959
      Location:645 → 845
      ARS2; Arsenite-resistance protein 2
      pfam12066
      Location:153 → 262
      DUF3546; Domain of unknown function (DUF3546)

    3. XM_039090060.2 → XP_038945988.1  serrate RNA effector molecule homolog isoform X2

      Conserved Domains (2) summary
      pfam04959
      Location:645 → 838
      ARS2; Arsenite-resistance protein 2
      pfam12066
      Location:153 → 262
      DUF3546; Domain of unknown function (DUF3546)

    4. XM_039090061.1 → XP_038945989.1  serrate RNA effector molecule homolog isoform X3

      Conserved Domains (2) summary
      pfam04959
      Location:548 → 752
      ARS2; Arsenite-resistance protein 2
      pfam12066
      Location:56 → 165
      DUF3546; Domain of unknown function (DUF3546)

    5. XM_039090062.2 → XP_038945990.1  serrate RNA effector molecule homolog isoform X4

      Conserved Domains (2) summary
      pfam04959
      Location:418 → 622
      ARS2; Arsenite-resistance protein 2
      pfam12066
      Location:1 → 35
      DUF3546; Domain of unknown function (DUF3546)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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