Mark4 microtubule affinity regulating kinase 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mark4provided by RGD
Official Full Name: microtubule affinity regulating kinase 4provided by RGD
Primary source: RGD:1591792
See related: EnsemblRapid:ENSRNOG00000017069 AllianceGenome:RGD:1591792
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable cytoskeletal anchor activity; tau-protein kinase activity; and tubulin binding activity. Predicted to be involved in several processes, including positive regulation of cellular component biogenesis; positive regulation of protein localization to centrosome; and regulation of centrosome cycle. Predicted to act upstream of or within positive regulation of cell cycle. Predicted to be located in several cellular components, including dendrite; microtubule organizing center; and midbody. Predicted to be part of gamma-tubulin complex. Predicted to be active in cytoplasm and microtubule organizing center. Orthologous to human MARK4 (microtubule affinity regulating kinase 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 46.2), Testes (RPKM 34.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q21

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (88203352..88239858, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (79075353..79108882, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (80335517..80367366, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interaction of Sp1 and Setd8 promotes vascular smooth muscle cells apoptosis by activating Mark4 in vascular calcification.
Title: Interaction of Sp1 and Setd8 promotes vascular smooth muscle cells apoptosis by activating Mark4 in vascular calcification.
MARK2 and MARK4 Regulate Sertoli Cell BTB Dynamics Through Microtubule and Actin Cytoskeletons.
Title: MARK2 and MARK4 Regulate Sertoli Cell BTB Dynamics Through Microtubule and Actin Cytoskeletons.
High MARK4 is associated with Alzheimer's disease.
Title: A critical role for the PAR-1/MARK-tau axis in mediating the toxic effects of Aβ on synapses and dendritic spines.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables cytoskeletal anchor activity	ISO Inferred from Sequence Orthology more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables gamma-tubulin binding	ISO Inferred from Sequence Orthology more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables microtubule binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info
enables tau-protein kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables tau-protein kinase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in cilium organization	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule bundle formation	ISO Inferred from Sequence Orthology more info
involved_in microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
NOT involved_in microtubule cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in microtubule cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in nervous system development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NLRP3 inflammasome complex assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to centrosome	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of centrosome cycle	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in ciliary basal body	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
part_of gamma-tubulin complex	ISO Inferred from Sequence Orthology more info
located_in microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info
is_active_in microtubule organizing center	ISO Inferred from Sequence Orthology more info
located_in microtubule organizing center	ISO Inferred from Sequence Orthology more info
located_in midbody	ISO Inferred from Sequence Orthology more info
located_in neuron projection	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: MAP/microtubule affinity-regulating kinase 4

NP_001178000.1

EC 2.7.11.1

XP_006228534.1

EC 2.7.11.1

XP_063129714.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001191071.1 → NP_001178000.1 MAP/microtubule affinity-regulating kinase 4

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A6J8N3, D4A6T9

Related

ENSRNOP00000023392.2, ENSRNOT00000023392.7

Conserved Domains (4) summary

cd12197
Location:654 → 752

MARK4_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 4

smart00220
Location:59 → 310

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14407
Location:328 → 370

UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins

cd14072
Location:58 → 310

STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

88203352..88239858 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006228472.5 → XP_006228534.1 MAP/microtubule affinity-regulating kinase 4 isoform X2

UniProtKB/TrEMBL

A0A0G2JTD8, A0A8I6A623

Related

ENSRNOP00000086560.1, ENSRNOT00000118826.2

Conserved Domains (3) summary

smart00220
Location:59 → 310

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14407
Location:328 → 370

UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins

cd14072
Location:58 → 310

STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
XM_063273644.1 → XP_063129714.1 MAP/microtubule affinity-regulating kinase 4 isoform X1

UniProtKB/TrEMBL

A6J8N3, D4A6T9