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    Nle1 notchless homolog 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303372, updated on 9-Dec-2024

    Summary

    Official Symbol
    Nle1provided by RGD
    Official Full Name
    notchless homolog 1provided by RGD
    Primary source
    RGD:1308301
    See related
    EnsemblRapid:ENSRNOG00000008287 AllianceGenome:RGD:1308301
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1308301
    Summary
    Predicted to be involved in regulation of Notch signaling pathway. Predicted to act upstream of or within several processes, including chordate embryonic development; hematopoietic stem cell homeostasis; and regulation of signal transduction. Predicted to be located in nucleoplasm. Predicted to be active in nucleolus. Orthologous to human NLE1 (notchless homolog 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 55.5), Muscle (RPKM 41.7) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Nle1 in Genome Data Viewer
    Location:
    10q26
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (68331609..68342562, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (67834059..67844771, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (70250959..70261880, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene RAD51 paralog D Neighboring gene U6 spliceosomal RNA Neighboring gene fibronectin type III domain containing 8 Neighboring gene unc-45 myosin chaperone B Neighboring gene schlafen family member 5

    Genomic regions, transcripts, and products

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    notchless protein homolog 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001127534.1NP_001121006.1  notchless protein homolog 1

      See identical proteins and their annotated locations for NP_001121006.1

      Status: PROVISIONAL

      Source sequence(s)
      BC166567
      UniProtKB/TrEMBL
      B2GV82, F7FIP9
      Related
      ENSRNOP00000011320.7, ENSRNOT00000011320.8
      Conserved Domains (4) summary
      COG2319
      Location:109487
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:108486
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam08154
      Location:1979
      NLE; NLE (NUC135) domain
      sd00039
      Location:161199
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      68331609..68342562 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006246995.5XP_006247057.1  notchless protein homolog 1 isoform X1

      See identical proteins and their annotated locations for XP_006247057.1

      UniProtKB/TrEMBL
      B2GV82, F7FIP9
      Conserved Domains (4) summary
      COG2319
      Location:109487
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:108486
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam08154
      Location:1979
      NLE; NLE (NUC135) domain
      sd00039
      Location:161199
      7WD40; WD40 repeat [structural motif]
    2. XM_006246994.5XP_006247056.1  notchless protein homolog 1 isoform X1

      See identical proteins and their annotated locations for XP_006247056.1

      UniProtKB/TrEMBL
      B2GV82, F7FIP9
      Conserved Domains (4) summary
      COG2319
      Location:109487
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:108486
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam08154
      Location:1979
      NLE; NLE (NUC135) domain
      sd00039
      Location:161199
      7WD40; WD40 repeat [structural motif]
    3. XM_063269084.1XP_063125154.1  notchless protein homolog 1 isoform X2

    4. XM_063269085.1XP_063125155.1  notchless protein homolog 1 isoform X2

    RNA

    1. XR_010055183.1 RNA Sequence

    2. XR_010055182.1 RNA Sequence