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    Lias lipoic acid synthetase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305348, updated on 9-Dec-2024

    Summary

    Official Symbol
    Liasprovided by RGD
    Official Full Name
    lipoic acid synthetaseprovided by RGD
    Primary source
    RGD:1307270
    See related
    EnsemblRapid:ENSRNOG00000002759 AllianceGenome:RGD:1307270
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable lipoate synthase activity. Predicted to be involved in lipoate biosynthetic process. Predicted to act upstream of or within several processes, including neural tube closure; response to lipopolysaccharide; and response to oxidative stress. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in pyruvate decarboxylase deficiency. Orthologous to human LIAS (lipoic acid synthetase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 190.8), Kidney (RPKM 161.7) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Lias in Genome Data Viewer
    Location:
    14p11
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (43230369..43247469, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (42876699..42893824, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (44507217..44524287, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein lateral stalk subunit P2 like 3 Neighboring gene small integral membrane protein 14 Neighboring gene UDP-glucose 6-dehydrogenase Neighboring gene ribosomal protein L9 Neighboring gene uncharacterized LOC134481848 Neighboring gene klotho beta

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding  
    enables lipoate synthase activity  
    enables lipoate synthase activity  
    enables metal ion binding  
    Component Evidence Code Pubs
    is_active_in mitochondrion  
    located_in mitochondrion  

    General protein information

    Preferred Names
    lipoyl synthase, mitochondrial
    Names
    LS
    lip-syn
    lipoate synthase
    lipoic acid synthase
    NP_001012037.1
    XP_038947848.1
    XP_063129204.1
    XP_063129205.1
    XP_063129206.1
    XP_063129207.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012037.1NP_001012037.1  lipoyl synthase, mitochondrial precursor

      See identical proteins and their annotated locations for NP_001012037.1

      Status: PROVISIONAL

      Source sequence(s)
      BC083708
      UniProtKB/Swiss-Prot
      Q5XIH4
      Related
      ENSRNOP00000003779.3, ENSRNOT00000003779.6
      Conserved Domains (1) summary
      PLN02428
      Location:41369
      PLN02428; lipoic acid synthase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      43230369..43247469 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063273137.1XP_063129207.1  lipoyl synthase, mitochondrial isoform X5

    2. XM_039091920.2XP_038947848.1  lipoyl synthase, mitochondrial isoform X3

      Conserved Domains (1) summary
      PLN02428
      Location:41326
      PLN02428; lipoic acid synthase
    3. XM_063273135.1XP_063129205.1  lipoyl synthase, mitochondrial isoform X2

    4. XM_063273134.1XP_063129204.1  lipoyl synthase, mitochondrial isoform X1

    5. XM_063273136.1XP_063129206.1  lipoyl synthase, mitochondrial isoform X4

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