Kcnd1 potassium voltage-gated channel subfamily D member 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kcnd1provided by RGD
Official Full Name: potassium voltage-gated channel subfamily D member 1provided by RGD
Primary source: RGD:621364
See related: EnsemblRapid:ENSRNOG00000039544 AllianceGenome:RGD:621364
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Kv4.1
Summary: Predicted to enable A-type (transient outward) potassium channel activity. Predicted to be involved in action potential and potassium ion transmembrane transport. Located in neuronal cell body. Orthologous to human KCND1 (potassium voltage-gated channel subfamily D member 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 9.6), Uterus (RPKM 7.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq12

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (17333612..17349255, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (14661688..14678745, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (15506724..15520712, complement)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

K(+) channel Kv4.1 is expressed in the nociceptors/secondary nociceptive neurons and participates in pain regulation.
Title: K(+) channel Kv4.1 is expressed in the nociceptors/secondary nociceptive neurons and participates in pain regulation.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables A-type (transient outward) potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables A-type (transient outward) potassium channel activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in action potential	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein homooligomerization	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in dendritic spine	IBA Inferred from Biological aspect of Ancestor more info
is_active_in neuronal cell body	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated potassium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated potassium channel complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: potassium voltage-gated channel subfamily D member 1

Names: potassium channel, voltage gated Shal-related subfamily D, member 1; potassium voltage gated channel Shal-related family member 1; potassium voltage-gated channel, Shal-related subfamily, member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001105748.1 → NP_001099218.1 potassium voltage-gated channel subfamily D member 1 precursor

See identical proteins and their annotated locations for NP_001099218.1

Status: PROVISIONAL

Source sequence(s)

CH474078

UniProtKB/TrEMBL

A6KP76, D3ZYK3

Related

ENSRNOP00000011994.1, ENSRNOT00000011994.5

Conserved Domains (3) summary

cl38908
Location:6 → 143

BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

pfam00520
Location:185 → 417

Ion_trans; Ion transport protein

pfam11879
Location:447 → 550

DUF3399; Domain of unknown function (DUF3399)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086039.1 Reference GRCr8

Range

17333612..17349255 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039099410.2 → XP_038955338.1 potassium voltage-gated channel subfamily D member 1 isoform X2

Conserved Domains (2) summary

pfam00520
Location:3 → 154

Ion_trans; Ion transport protein

pfam11879
Location:184 → 287

DUF3399; Domain of unknown function (DUF3399)
XM_039099409.2 → XP_038955337.1 potassium voltage-gated channel subfamily D member 1 isoform X1

UniProtKB/TrEMBL

A6KP76, D3ZYK3

Conserved Domains (3) summary

cl38908
Location:6 → 143

BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

pfam00520
Location:185 → 417

Ion_trans; Ion transport protein

pfam11879
Location:447 → 550

DUF3399; Domain of unknown function (DUF3399)
XM_063279755.1 → XP_063135825.1 potassium voltage-gated channel subfamily D member 1 isoform X1

UniProtKB/TrEMBL

A6KP76, D3ZYK3