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    Tmem14c transmembrane protein 14C [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171432, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Tmem14cprovided by RGD
    Official Full Name
    transmembrane protein 14Cprovided by RGD
    Primary source
    RGD:621692
    See related
    EnsemblRapid:ENSRNOG00000015437 AllianceGenome:RGD:621692
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cdtw1
    Summary
    Predicted to be involved in regulation of heme biosynthetic process. Predicted to act upstream of or within erythrocyte differentiation; mitochondrial transport; and nitrogen compound transport. Predicted to be located in mitochondrial inner membrane. Predicted to be active in mitochondrial membrane. Orthologous to several human genes including TMEM14C (transmembrane protein 14C). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Adrenal (RPKM 806.1), Spleen (RPKM 787.2) and 9 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tmem14c in Genome Data Viewer
    Location:
    17p12
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (23939501..23945622, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (23733769..23739906, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (21571510..21577651, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene glial cells missing transcription factor 2 Neighboring gene male germ cell-associated kinase Neighboring gene uncharacterized LOC134482840 Neighboring gene PAK1 interacting protein 1 Neighboring gene similar to human chromosome 6 open reading frame 52

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. TMEM14C is required for erythroid mitochondrial heme metabolism. Yien YY, et al. J Clin Invest, 2014 Oct. PMID 25157825, Free PMC Article
    2. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853
    3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within erythrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in heme biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within mitochondrial transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within nitrogen compound transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of heme biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of heme biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrial membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 14C
    Names
    P11 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001135169.2 → NP_001128641.1  transmembrane protein 14C

      See identical proteins and their annotated locations for NP_001128641.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks a segment in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC158854, CB744788, CV107072
      UniProtKB/TrEMBL
      A6JGV3, B0BNJ9, F7FLK4
      Related
      ENSRNOP00000101126.1, ENSRNOT00000155376.1
      Conserved Domains (1) summary
      pfam03647
      Location:13 → 102
      Tmemb_14; Transmembrane proteins 14C

    2. NM_134395.2 → NP_599222.2  transmembrane protein 14C

      See identical proteins and their annotated locations for NP_599222.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AF083396, CV107072
      UniProtKB/TrEMBL
      A6JGV3, B0BNJ9, F7FLK4
      Conserved Domains (1) summary
      pfam03647
      Location:13 → 102
      Tmemb_14; Transmembrane proteins 14C

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      23939501..23945622 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006253777.5 → XP_006253839.1  transmembrane protein 14C isoform X1

      See identical proteins and their annotated locations for XP_006253839.1

      UniProtKB/TrEMBL
      A6JGV3, B0BNJ9, F7FLK4
      Conserved Domains (1) summary
      pfam03647
      Location:13 → 102
      Tmemb_14; Transmembrane proteins 14C

    2. XM_039095319.2 → XP_038951247.1  transmembrane protein 14C isoform X1

      UniProtKB/TrEMBL
      A6JGV3, B0BNJ9, F7FLK4
      Conserved Domains (1) summary
      pfam03647
      Location:13 → 102
      Tmemb_14; Transmembrane proteins 14C
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q924P2.1 GenPept UniProtKB/Swiss-Prot:Q924P2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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