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    cdc37 Hsp90 co-chaperone Cdc37 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2541293, updated on 18-Sep-2024

    Summary

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    Official Symbol
    cdc37
    Official Full Name
    Hsp90 co-chaperone Cdc37
    Primary source
    PomBase:SPBC9B6.10
    Locus tag
    SPOM_SPBC9B6.10
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See cdc37 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    4
    Sequence:
    Chromosome: II; NC_003423.3 (1831087..1833130)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene clathrin light chain Clc1 Neighboring gene peptide-transporting ATPase Neighboring gene CCR4/nocturin family endoribonuclease Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Schizosaccharomyces pombe Cdc7 protein kinase required for septum formation is a client protein of Cdc37. Liang J, et al. Eukaryot Cell, 2007 Jul. PMID 17496123, Free PMC Article
    2. Activity of Cdc2 and its interaction with the cyclin Cdc13 depend on the molecular chaperone Cdc37 in Schizosaccharomyces pombe. Turnbull EL, et al. J Cell Sci, 2006 Jan 15. PMID 16390871
    3. Cdc37 maintains cellular viability in Schizosaccharomyces pombe independently of interactions with heat-shock protein 90. Turnbull EL, et al. FEBS J, 2005 Aug. PMID 16098195
    4. Identification of Cdc37 as a novel regulator of the stress-responsive mitogen-activated protein kinase. Tatebe H, et al. Mol Cell Biol, 2003 Aug. PMID 12861001, Free PMC Article
    5. Dual recruitment of Cdc48 (p97)-Ufd1-Npl4 ubiquitin-selective segregase by small ubiquitin-like modifier protein (SUMO) and ubiquitin in SUMO-targeted ubiquitin ligase-mediated genome stability functions. Nie M, et al. J Biol Chem, 2012 Aug 24. PMID 22730331, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results show that the Schizosaccharomyces pombe Cdc7 protein kinase required for septum formation is a client protein of Cdc37.
      Title: The Schizosaccharomyces pombe Cdc7 protein kinase required for septum formation is a client protein of Cdc37.
    2. Data suggest that Cdc2 is a likely client for the Cdc37 molecular chaperone, and that inactivation of Cdc2 appears to result from the inability to form complexes with its mitotic cyclin partner Cdc13.
      Title: Activity of Cdc2 and its interaction with the cyclin Cdc13 depend on the molecular chaperone Cdc37 in Schizosaccharomyces pombe.
    3. The N-terminal domain of the chaperone Cdc37 carries out essential functions independently of the homodimerization and Hsp90-binding domains. [cdc37]
      Title: Cdc37 maintains cellular viability in Schizosaccharomyces pombe independently of interactions with heat-shock protein 90.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables heat shock protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables heat shock protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-folding chaperone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein folding IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein stabilization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol HDA PubMed 
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Hsp90 co-chaperone Cdc37

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      1831087..1833130
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001021652.3 → NP_595752.1  Hsp90 co-chaperone Cdc37 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_595752.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O94740
      Conserved Domains (3) summary
      smart01071
      Location:2 → 181
      CDC37_N; Cdc37 N terminal kinase binding
      pfam08564
      Location:386 → 453
      CDC37_C; Cdc37 C terminal domain
      pfam08565
      Location:252 → 363
      CDC37_M; Cdc37 Hsp90 binding domain
    Nucleotide Protein
    Heading Accession and Version

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