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    upf2 nonsense-mediated decay protein Upf2 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2542147, updated on 18-Sep-2024

    Summary

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    Official Symbol
    upf2
    Official Full Name
    nonsense-mediated decay protein Upf2
    Primary source
    PomBase:SPAC19A8.08
    Locus tag
    SPOM_SPAC19A8.08
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See upf2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_003424.3 (2468576..2472061, complement)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene recombination protein Irc6 Neighboring gene SUMO-targeted ubiquitin-protein ligase subunit Rfp1 Neighboring gene ncRNA Neighboring gene transport protein Yos1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene protein prl65

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Upf1, an RNA helicase required for nonsense-mediated mRNA decay, modulates the transcriptional response to oxidative stress in fission yeast. Rodríguez-Gabriel MA, et al. Mol Cell Biol, 2006 Sep. PMID 16914721, Free PMC Article
    2. Novel Upf2p orthologues suggest a functional link between translation initiation and nonsense surveillance complexes. Mendell JT, et al. Mol Cell Biol, 2000 Dec. PMID 11073994, Free PMC Article
    3. Schizosaccharomyces pombe centromere protein Mis19 links Mis16 and Mis18 to recruit CENP-A through interacting with NMD factors and the SWI/SNF complex. Hayashi T, et al. Genes Cells, 2014 Jul. PMID 24774534
    4. ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe. Matsuyama A, et al. Nat Biotechnol, 2006 Jul. PMID 16823372
    5. Transcription and RNA-processing in fission yeast mitochondria. Schäfer B, et al. RNA, 2005 May. PMID 15811919, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of mRNA stability involved in response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol HDA PubMed 
    part_of exon-exon junction complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    nonsense-mediated decay protein Upf2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      2468576..2472061 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001019213.2 → NP_593784.1  nonsense-mediated decay protein Upf2 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_593784.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O13824
      Conserved Domains (4) summary
      smart00543
      Location:447 → 634
      MIF4G; Middle domain of eukaryotic initiation factor 4G (eIF4G)
      pfam02854
      Location:649 → 855
      MIF4G; MIF4G domain
      pfam04050
      Location:901 → 1047
      Upf2; Up-frameshift suppressor 2
      cl02652
      Location:41 → 281
      MIF4G; MIF4G domain
    Nucleotide Protein
    Heading Accession and Version

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