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    rpn8 proteasome regulatory subunit Rpn8 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2538912, updated on 18-Sep-2024

    Summary

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    Official Symbol
    rpn8
    Official Full Name
    proteasome regulatory subunit Rpn8
    Primary source
    PomBase:SPCC1682.10
    Locus tag
    SPOM_SPCC1682.10
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See rpn8 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    2
    Sequence:
    Chromosome: III; NC_003421.2 (390694..392092)

    Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene meiotic pumilio family RNA-binding protein Mpf2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene guanine nucleotide transporter Neighboring gene choline transmembrane transporter family protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ubiquitin hydrolase Ubp16 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003421.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Fission yeast Dss1 associates with the proteasome and is required for efficient ubiquitin-dependent proteolysis. Jossé L, et al. Biochem J, 2006 Jan 1. PMID 16149916, Free PMC Article
    2. Structure of the 26S proteasome from Schizosaccharomyces pombe at subnanometer resolution. Bohn S, et al. Proc Natl Acad Sci U S A, 2010 Dec 7. PMID 21098295, Free PMC Article
    3. The 19S proteasome is directly involved in the regulation of heterochromatin spreading in fission yeast. Seo HD, et al. J Biol Chem, 2017 Oct 13. PMID 28784663, Free PMC Article
    4. Chemical cross-linking/mass spectrometry targeting acidic residues in proteins and protein complexes. Leitner A, et al. Proc Natl Acad Sci U S A, 2014 Jul 1. PMID 24938783, Free PMC Article
    5. Synergistic roles of the proteasome and autophagy for mitochondrial maintenance and chronological lifespan in fission yeast. Takeda K, et al. Proc Natl Acad Sci U S A, 2010 Feb 23. PMID 20133687, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol HDA PubMed 
    is_active_in mitotic spindle midzone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nuclear envelope HDA PubMed 
    is_active_in nucleus HDA PubMed 
    part_of proteasome complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proteasome regulatory particle, lid subcomplex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    proteasome regulatory subunit Rpn8

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003421.2 Reference assembly

      Range
      390694..392092
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001022796.3 → NP_587803.1  proteasome regulatory subunit Rpn8 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_587803.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O74440
      Conserved Domains (2) summary
      cd08062
      Location:15 → 304
      MPN_RPN7_8; Mpr1p, Pad1p N-terminal (MPN) domains without catalytic isopeptidase activity, found in 19S proteasomal subunits Rpn7 and Rpn8
      PLN03246
      Location:14 → 304
      PLN03246; 26S proteasome regulatory subunit; Provisional
    Nucleotide Protein
    Heading Accession and Version

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