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    erg5 C-22 sterol desaturase Erg5 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2542469, updated on 18-Sep-2024

    Summary

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    Official Symbol
    erg5
    Official Full Name
    C-22 sterol desaturase Erg5
    Primary source
    PomBase:SPAC19A8.04
    Locus tag
    SPOM_SPAC19A8.04
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    cyp61
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    Genomic context

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    See erg5 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    2
    Sequence:
    Chromosome: I; NC_003424.3 (2480065..2482169, complement)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene putative dehydrogenase Neighboring gene ncRNA Neighboring gene ESCRT 0 complex subunit sst4 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene myotubularin family phosphatidylinositol-3-phosphatase Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dap1/PGRMC1 binds and regulates cytochrome P450 enzymes. Hughes AL, et al. Cell Metab, 2007 Feb. PMID 17276356
    2. A genetic and pharmacological analysis of isoprenoid pathway by LC-MS/MS in fission yeast. Takami T, et al. PLoS One, 2012. PMID 23145048, Free PMC Article
    3. Multiple functions of ergosterol in the fission yeast Schizosaccharomyces pombe. Iwaki T, et al. Microbiology (Reading), 2008 Mar. PMID 18310029
    4. Inner nuclear membrane proteins Lem2 and Bqt4 interact with different lipid synthesis enzymes in fission yeast. Hirano Y, et al. J Biochem, 2023 Jun 30. PMID 36799444
    5. The fission yeast FLCN/FNIP complex augments TORC1 repression or activation in response to amino acid (AA) availability. Calvo IA, et al. iScience, 2021 Nov 19. PMID 34805795, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables C-22 sterol desaturase (NADPH) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables heme binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ergosterol biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ergosterol biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    C-22 sterol desaturase Erg5

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      2480065..2482169 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001019217.3 → NP_593788.2  C-22 sterol desaturase Erg5 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_593788.2

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O13820
      Conserved Domains (1) summary
      COG2124
      Location:57 → 505
      CypX; Cytochrome P450 [Secondary metabolites biosynthesis, transport and catabolism, Defense mechanisms]
    Nucleotide Protein
    Heading Accession and Version

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