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    leu2 3-isopropylmalate dehydratase Leu2 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2543296, updated on 18-Sep-2024

    Summary

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    Official Symbol
    leu2
    Official Full Name
    3-isopropylmalate dehydratase Leu2
    Primary source
    PomBase:SPAC9E9.03
    Locus tag
    SPOM_SPAC9E9.03
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See leu2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_003424.3 (4439855..4442513)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene bcap family protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic Mapping in SCHIZOSACCHAROMYCES POMBE by Mitotic and Meiotic Analysis and Induced Haploidization. Kohli J, et al. Genetics, 1977 Nov. PMID 17248775, Free PMC Article
    2. Characterization of Mug33 reveals complementary roles for actin cable-dependent transport and exocyst regulators in fission yeast exocytosis. Snaith HA, et al. J Cell Sci, 2011 Jul 1. PMID 21652630, Free PMC Article
    3. Proximity-dependent biotinylation mediated by TurboID to identify protein-protein interaction networks in yeast. Larochelle M, et al. J Cell Sci, 2019 May 31. PMID 31064814
    4. Yeast X-chromosome-associated protein 5 (Xap5) functions with H2A.Z to suppress aberrant transcripts. Anver S, et al. EMBO Rep, 2014 Aug. PMID 24957674, Free PMC Article
    5. A non-transcriptional role for the glucocorticoid receptor in mediating the cell stress response. Ptushkina M, et al. Sci Rep, 2017 Sep 21. PMID 28935859, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables 3-isopropylmalate dehydratase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-leucine biosynthetic process EXP
    Inferred from Experiment
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    3-isopropylmalate dehydratase Leu2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      4439855..4442513
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001020005.3 → NP_594576.1  3-isopropylmalate dehydratase Leu2 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_594576.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O14289
      Conserved Domains (3) summary
      PRK01641
      Location:539 → 734
      leuD; isopropylmalate isomerase small subunit; Provisional
      PRK05478
      Location:7 → 478
      PRK05478; isopropylmalate isomerase large subunit; Validated
      TIGR01340
      Location:8 → 681
      aconitase_mito; aconitate hydratase, mitochondrial
    Nucleotide Protein
    Heading Accession and Version

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