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    his4 imidazoleglycerol-phosphate synthase [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2541224, updated on 14-Nov-2024

    Summary

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    Official Symbol
    his4
    Official Full Name
    imidazoleglycerol-phosphate synthase
    Primary source
    PomBase:SPBC418.01c
    Locus tag
    SPOM_SPBC418.01C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    SPBC887.20c
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    Genomic context

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    See his4 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    2
    Sequence:
    Chromosome: II; NC_003423.3 (3581989..3583840, complement)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene transmembrane transporter Neighboring gene ncRNA Neighboring gene SAGA complex subunit Hfi1/Ada1 Neighboring gene ncRNA Neighboring gene Man5GlcNac2-PP-Dol translocation protein Rft1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene NatA N-acetyltransferase complex subunit Neighboring gene protein acl4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Caffeine-resistance in S. pombe: mutations in three novel caf genes increase caffeine tolerance and affect radiation sensitivity, fertility, and cell cycle. Benko Z, et al. Curr Genet, 1997 Jun. PMID 9211790
    2. Hierarchical modularity and the evolution of genetic interactomes across species. Ryan CJ, et al. Mol Cell, 2012 Jun 8. PMID 22681890, Free PMC Article
    3. ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe. Matsuyama A, et al. Nat Biotechnol, 2006 Jul. PMID 16823372
    4. Transcription and RNA-processing in fission yeast mitochondria. Schäfer B, et al. RNA, 2005 May. PMID 15811919, Free PMC Article
    5. The genome sequence of Schizosaccharomyces pombe. Wood V, et al. Nature, 2002 Feb 21. PMID 11859360

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables glutaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables imidazoleglycerol-phosphate synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-histidine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol HDA PubMed 
    is_active_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    imidazoleglycerol-phosphate synthase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      3581989..3583840 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001022414.3 → NP_596494.2  imidazoleglycerol-phosphate synthase [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_596494.2

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O94303, Q9Y7X3
      Conserved Domains (3) summary
      cd01748
      Location:3 → 205
      GATase1_IGP_Synthase; Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS)
      PLN02617
      Location:3 → 541
      PLN02617; imidazole glycerol phosphate synthase hisHF
      COG0107
      Location:227 → 540
      HisF; Imidazole glycerol phosphate synthase subunit HisF [Amino acid transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version

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