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    mag2 DNA-3-methyladenine glycosylase Mag2 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2540646, updated on 18-Sep-2024

    Summary

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    Official Symbol
    mag2
    Official Full Name
    DNA-3-methyladenine glycosylase Mag2
    Primary source
    PomBase:SPBC23G7.11
    Locus tag
    SPOM_SPBC23G7.11
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See mag2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_003423.3 (2120257..2121050)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene NADH-dependent flavin oxidoreductase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene proteasome regulatory subunit Rpt6

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Non-productive DNA damage binding by DNA glycosylase-like protein Mag2 from Schizosaccharomyces pombe. Adhikary S, et al. DNA Repair (Amst), 2013 Mar 1. PMID 23273506, Free PMC Article
    2. Sculpting of DNA at abasic sites by DNA glycosylase homolog mag2. Dalhus B, et al. Structure, 2013 Jan 8. PMID 23245849, Free PMC Article
    3. Involvement of 3-methyladenine DNA glycosylases Mag1p and Mag2p in base excision repair of methyl methanesulfonate-damaged DNA in the fission yeast Schizosaccharomyces pombe. Kanamitsu K, et al. Genes Genet Syst, 2007 Dec. PMID 18270439
    4. Fission yeast homologs of human XPC and CSB, rhp41 and rhp26, are involved in transcription-coupled repair of methyl methanesulfonate-induced DNA damage. Kanamitsu K, et al. Genes Genet Syst, 2011. PMID 21670547
    5. Large scale screening of genetic interaction with sgf73(+) in fission yeast. Guo Y, et al. Yi Chuan, 2014 Jul. PMID 25076038

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Novel insight into the chemical and physical determinants by which Mag2 engages DNA in a catalytically productive manner.
      Title: Non-productive DNA damage binding by DNA glycosylase-like protein Mag2 from Schizosaccharomyces pombe.
    2. The molecular role of Mag2 appears to be apurinic site recognition and protection.
      Title: Sculpting of DNA at abasic sites by DNA glycosylase homolog mag2.
    3. Involvement of 3-methyladenine DNA glycosylases Mag2p in base excision repair of methyl methanesulfonate-damaged DNA in the fission yeast Schizosaccharomyces pombe.(
      Title: Involvement of 3-methyladenine DNA glycosylases Mag1p and Mag2p in base excision repair of methyl methanesulfonate-damaged DNA in the fission yeast Schizosaccharomyces pombe.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-(abasic site) binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables alkylated DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT enables alkylbase DNA N-glycosylase activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    NOT enables alkylbase DNA N-glycosylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    NOT involved_in DNA alkylation repair EXP
    Inferred from Experiment
    more info
    		 PubMed 
    NOT involved_in base-excision repair EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in base-excision repair, AP site formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    NOT involved_in nucleotide-excision repair EXP
    Inferred from Experiment
    more info
    		 PubMed 
    NOT involved_in recombinational repair EXP
    Inferred from Experiment
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein-DNA complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    DNA-3-methyladenine glycosylase Mag2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      2120257..2121050
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001021775.3 → NP_595869.1  DNA-3-methyladenine glycosylase Mag2 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_595869.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O94468
      Conserved Domains (2) summary
      COG0122
      Location:1 → 213
      AlkA; 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [Replication, recombination and repair]
      pfam00730
      Location:46 → 193
      HhH-GPD; HhH-GPD superfamily base excision DNA repair protein
    Nucleotide Protein
    Heading Accession and Version

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