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    rpt3 proteasome regulatory subunit Rpt3 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2539539, updated on 18-Sep-2024

    Summary

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    Official Symbol
    rpt3
    Official Full Name
    proteasome regulatory subunit Rpt3
    Primary source
    PomBase:SPCC576.10c
    Locus tag
    SPOM_SPCC576.10C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See rpt3 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_003421.2 (2097289..2098866, complement)

    Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene 40S ribosomal protein uS5 Neighboring gene ncRNA Neighboring gene 40S ribosomal protein uS10 Neighboring gene 60S ribosomal protein eL15 Neighboring gene FANCM-MHF complex subunit Mhf2 Neighboring gene Swr1 complex subunit Swc5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003421.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of 15 New Bypassable Essential Genes of Fission Yeast. Takeda A, et al. Cell Struct Funct, 2019 Sep 27. PMID 31474649, Free PMC Article
    2. The 19S proteasome subunit Rpt3 regulates distribution of CENP-A by associating with centromeric chromatin. Kitagawa T, et al. Nat Commun, 2014 Apr 7. PMID 24710126
    3. Fission yeast Dss1 associates with the proteasome and is required for efficient ubiquitin-dependent proteolysis. Jossé L, et al. Biochem J, 2006 Jan 1. PMID 16149916, Free PMC Article
    4. Molecular architecture of the 26S proteasome holocomplex determined by an integrative approach. Lasker K, et al. Proc Natl Acad Sci U S A, 2012 Jan 31. PMID 22307589, Free PMC Article
    5. Structure of the 26S proteasome from Schizosaccharomyces pombe at subnanometer resolution. Bohn S, et al. Proc Natl Acad Sci U S A, 2010 Dec 7. PMID 21098295, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. rpt3 mutation disrupts CENP-A distribution due to loss of centromeric chromatin association.
      Title: The 19S proteasome subunit Rpt3 regulates distribution of CENP-A by associating with centromeric chromatin.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity NAS
    Non-traceable Author Statement
    more info
    		  
    enables proteasome-activating activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables proteasome-activating activity ISM
    Inferred from Sequence Model
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IC
    Inferred by Curator
    more info
    		  
    Component Evidence Code Pubs
    is_active_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm HDA PubMed 
    is_active_in cytosol HDA PubMed 
    is_active_in nuclear periphery IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of proteasome regulatory particle, base subcomplex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proteasome regulatory particle, base subcomplex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    proteasome regulatory subunit Rpt3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003421.2 Reference assembly

      Range
      2097289..2098866 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001023428.3 → NP_588437.1  proteasome regulatory subunit Rpt3 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_588437.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O74894
      Conserved Domains (3) summary
      PTZ00454
      Location:2 → 389
      PTZ00454; 26S protease regulatory subunit 6B-like protein; Provisional
      pfam00004
      Location:171 → 303
      AAA; ATPase family associated with various cellular activities (AAA)
      cl21455
      Location:99 → 235
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein
    Heading Accession and Version

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