U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    cdc15 F-BAR domain protein Cdc15 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2541975, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    cdc15
    Official Full Name
    F-BAR domain protein Cdc15
    Primary source
    PomBase:SPAC20G8.05c
    Locus tag
    SPOM_SPAC20G8.05C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See cdc15 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    4
    Sequence:
    Chromosome: I; NC_003424.3 (1399200..1402936, complement)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene plasma membrane myo-inositol transmembrane transporter Neighboring gene electron transfer flavoprotein-ubiquinone oxidoreductase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene CCR4-Not complex subunit Not1 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Organization of a sterol-rich membrane domain by cdc15p during cytokinesis in fission yeast. Takeda T, et al. Nat Cell Biol, 2004 Nov. PMID 15517003
    2. Contractile ring stability in S. pombe depends on F-BAR protein Cdc15p and Bgs1p transport from the Golgi complex. Arasada R, et al. Cell Rep, 2014 Sep 11. PMID 25159149, Free PMC Article
    3. Fission yeast paxillin contains two Cdc15 binding motifs for robust recruitment to the cytokinetic ring. Snider CE, et al. Mol Biol Cell, 2022 Apr 1. PMID 35108037, Free PMC Article
    4. The Tubulation Activity of a Fission Yeast F-BAR Protein Is Dispensable for Its Function in Cytokinesis. McDonald NA, et al. Cell Rep, 2016 Jan 26. PMID 26776521, Free PMC Article
    5. The S. pombe cdc15 gene is a key element in the reorganization of F-actin at mitosis. Fankhauser C, et al. Cell, 1995 Aug 11. PMID 7634333

    See all (79) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Multiple polarity kinases inhibit phase separation of F-BAR protein Cdc15 and antagonize cytokinetic ring assembly in fission yeast.
      Title: Multiple polarity kinases inhibit phase separation of F-BAR protein Cdc15 and antagonize cytokinetic ring assembly in fission yeast.
    2. Cdk1 phosphorylation of formin Cdc12 antagonizes its interaction with Cdc15 and thereby opposes Cdc12's contractile ring localization. These results are consistent with a general role for Cdk1 in inhibiting cytokinesis until chromosome segregation is complete.
      Title: Cdk1-dependent phosphoinhibition of a formin-F-BAR interaction opposes cytokinetic contractile ring formation.
    3. Septation initiation network and Clp1p/Flp1p contribute to maintenance of the actomyosin ring in late mitosis through Cdc15p, possibly by regulating its phosphorylation status.(Cdc15) (actomyosin)
      Title: Cell cycle-dependent roles for the FCH-domain protein Cdc15p in formation of the actomyosin ring in Schizosaccharomyces pombe.
    4. Data indicate that the SH3 domains of Cdc15 and contractile ring protein Imp2 cooperate in the essential process of recruiting other proteins to stabilize the contractile ring.
      Title: The Cdc15 and Imp2 SH3 domains cooperatively scaffold a network of proteins that redundantly ensure efficient cell division in fission yeast.
    5. Cdc15p associates with trans-Golgi membranes through its middle domain and controls Bgs1 delivery from the Golgi apparatus to the plasma membrane.
      Title: Contractile ring stability in S. pombe depends on F-BAR protein Cdc15p and Bgs1p transport from the Golgi complex.
    6. Cdc15 contributes to contractile ring formation and cytokinesis via formin Cdc12 recruitment, defining a novel cytokinetic function for an F-BAR domain.
      Title: The F-BAR Cdc15 promotes contractile ring formation through the direct recruitment of the formin Cdc12.
    7. The F-BAR proteins Cdc15p and Bzz1p accumulate in two distinct zones on invaginating membrane tubules, interacting with nucleation-promoting factors for Arp2/3 complex. They peak prior to movement of the actin patch.
      Title: Distinct roles for F-BAR proteins Cdc15p and Bzz1p in actin polymerization at sites of endocytosis in fission yeast.
    8. Cdc15 phosphoregulation impels both assembly and disassembly of the contractile apparatus.
      Title: Dephosphorylation of F-BAR protein Cdc15 modulates its conformation and stimulates its scaffolding activity at the cell division site.
    9. The SH3 domains of Cdc15 and Imp2 play a cooperative and essential role in cytokinesis.
      Title: The SH3 domains of two PCH family members cooperate in assembly of the Schizosaccharomyces pombe contractile ring.
    10. cdc15p functions to organize lipid rafts at the cleavage site for cytokinesis
      Title: Organization of a sterol-rich membrane domain by cdc15p during cytokinesis in fission yeast.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables cytoskeletal protein-membrane anchor activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables cytoskeletal protein-membrane anchor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cytoskeletal protein-membrane anchor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables cytoskeletal protein-membrane anchor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phospholipid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in clathrin-dependent endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in establishment of bipolar cell polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    NOT involved_in membrane bending IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic actomyosin contractile ring assembly EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in mitotic actomyosin contractile ring assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mitotic actomyosin contractile ring assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in actin cortical patch IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cell division site HDA PubMed 
    is_active_in cell division site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cell division site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cell tip HDA PubMed 
    is_active_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasmic side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasmic side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mating projection tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in medial cortical node IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in medial membrane band IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitotic actomyosin contractile ring IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitotic actomyosin contractile ring, proximal layer IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitotic actomyosin contractile ring, proximal layer IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    F-BAR domain protein Cdc15

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      1399200..1402936 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001018753.3 → NP_593322.1  F-BAR domain protein Cdc15 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_593322.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O14365, Q09822, Q9UU50
      Conserved Domains (2) summary
      cd07651
      Location:28 → 263
      F-BAR_PombeCdc15_like; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Schizosaccharomyces pombe Cdc15, and similar proteins
      smart00326
      Location:869 → 925
      SH3; Src homology 3 domains
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Miscellaneous