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    loz1 zf-C2H2 type transcription factor [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2542738, updated on 18-Sep-2024

    Summary

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    Official Symbol
    loz1
    Official Full Name
    zf-C2H2 type transcription factor
    Primary source
    PomBase:SPAC25B8.19c
    Locus tag
    SPOM_SPAC25B8.19C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    SPAC683.01c
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    Genomic context

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    See loz1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_003424.3 (4192070..4195213, complement)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene intramembrane aspartyl protease of the perinuclear ER membrane Ypf1 Neighboring gene ncRNA Neighboring gene electron carrier protein Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Loz1 transcription factor from Schizosaccharomyces pombe binds to Loz1 response elements and represses gene expression when zinc is in excess. Wilson S, et al. Mol Microbiol, 2019 Dec. PMID 31515876, Free PMC Article
    2. The double zinc finger domain and adjacent accessory domain from the transcription factor loss of zinc sensing 1 (loz1) are necessary for DNA binding and zinc sensing. Ehrensberger KM, et al. J Biol Chem, 2014 Jun 27. PMID 24831008, Free PMC Article
    3. Zinc-dependent activation of the Pho8 alkaline phosphatase in Schizosaccharomyces pombe. Hu YM, et al. J Biol Chem, 2019 Aug 16. PMID 31239353, Free PMC Article
    4. Zinc finger protein Loz1 is required for zinc-responsive regulation of gene expression in fission yeast. Corkins ME, et al. Proc Natl Acad Sci U S A, 2013 Sep 17. PMID 24003116, Free PMC Article
    5. The gluconate shunt is an alternative route for directing glucose into the pentose phosphate pathway in fission yeast. Corkins ME, et al. J Biol Chem, 2017 Aug 18. PMID 28667014, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The double zinc finger domain and adjacent accessory domain of loz1 are necessary for DNA binding and zinc sensing.
      Title: The double zinc finger domain and adjacent accessory domain from the transcription factor loss of zinc sensing 1 (loz1) are necessary for DNA binding and zinc sensing.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intracellular zinc ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    zf-C2H2 type transcription factor

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      4192070..4195213 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001019908.3 → NP_594479.2  zf-C2H2 type transcription factor [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_594479.2

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q9HFF3, Q9UTA1
      Conserved Domains (2) summary
      sd00017
      Location:470 → 490
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:482 → 508
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein
    Heading Accession and Version

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    Research Materials