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    erf2 palmitoyltransferase Erf2 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2541058, updated on 18-Sep-2024

    Summary

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    Official Symbol
    erf2
    Official Full Name
    palmitoyltransferase Erf2
    Primary source
    PomBase:SPBC3H7.09
    Locus tag
    SPOM_SPBC3H7.09
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    mug142
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    Genomic context

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    See erf2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_003423.3 (1865821..1867532, complement)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene protein tam8 Neighboring gene elongator complex subunit Elp6 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene phosphoserine phosphatase Ser2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Distinct functional relevance of dynamic GTPase cysteine methylation in fission yeast. Franco A, et al. Sci Rep, 2017 Jul 20. PMID 28729673, Free PMC Article
    2. Quantitative control of protein S-palmitoylation regulates meiotic entry in fission yeast. Zhang MM, et al. PLoS Biol, 2013 Jul. PMID 23843742, Free PMC Article
    3. Rho2 palmitoylation is required for plasma membrane localization and proper signaling to the fission yeast cell integrity mitogen- activated protein kinase pathway. Sánchez-Mir L, et al. Mol Cell Biol, 2014 Jul. PMID 24820419, Free PMC Article
    4. Regulation of Ras localization and cell transformation by evolutionarily conserved palmitoyltransferases. Young E, et al. Mol Cell Biol, 2014 Feb. PMID 24248599, Free PMC Article
    5. Protein S-palmitoylation regulates different stages of meiosis in Schizosaccharomyces pombe. Pham TV, et al. Life Sci Alliance, 2023 Apr. PMID 36650056, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results shpw that Rho2 is an in vivo substrate for Erf2 palmitoyltransferase.
      Title: Rho2 palmitoylation is required for plasma membrane localization and proper signaling to the fission yeast cell integrity mitogen- activated protein kinase pathway.
    2. Data indicate that sp-Erf2/zDHHC9 palmitoylates Ras proteins in a highly selective manner in the trans-Golgi compartment to facilitate PM targeting via the trans-Golgi network, a role that is most certainly critical for Ras-driven tumorigenesis.
      Title: Regulation of Ras localization and cell transformation by evolutionarily conserved palmitoyltransferases.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables protein-cysteine S-palmitoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-cysteine S-palmitoyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein targeting to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus HDA PubMed 
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of endoplasmic reticulum palmitoyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    palmitoyltransferase Erf2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      1865821..1867532 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001021667.3 → NP_595766.1  palmitoyltransferase Erf2 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_595766.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O74384
      Conserved Domains (1) summary
      COG5273
      Location:57 → 350
      COG5273; Uncharacterized protein containing DHHC-type Zn finger [General function prediction only]
    Nucleotide Protein
    Heading Accession and Version

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