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    nhe1 plasma membrane/prospore membrane sodium ion/proton antiporter Nhe1/Sod2 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2543239, updated on 18-Sep-2024

    Summary

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    Official Symbol
    nhe1
    Official Full Name
    plasma membrane/prospore membrane sodium ion/proton antiporter Nhe1/Sod2
    Primary source
    PomBase:SPAC977.10
    Locus tag
    SPOM_SPAC977.10
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    sod2
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    Genomic context

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    See nhe1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    2
    Sequence:
    Chromosome: I; NC_003424.3 (51989..53858)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene plasma membrane fluoride export channel Fex1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure and function of yeast and fungal Na(+) /H(+) antiporters. Dutta D, et al. IUBMB Life, 2018 Jan. PMID 29219228
    2. Functional role and analysis of cysteine residues of the salt tolerance protein Sod2. Ullah A, et al. Mol Cell Biochem, 2014 Jan. PMID 24104454
    3. Structural and functional analysis of transmembrane segment IV of the salt tolerance protein Sod2. Ullah A, et al. J Biol Chem, 2013 Aug 23. PMID 23836910, Free PMC Article
    4. Functional analysis of amino acid residues essential for activity in the Na+/H+ exchanger of fission yeast. Dibrov P, et al. Biochemistry, 1998 Jun 9. PMID 9622480
    5. Proline 146 is critical to the structure, function and targeting of sod2, the Na+/H+ exchanger of Schizosaccharomyces pombe. Ndayizeye M, et al. Biochim Biophys Acta, 2009 May. PMID 19171118

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structure and function of an Na(+)/H(+) antiporter has been described. (Review)
      Title: Structure and function of yeast and fungal Na(+) /H(+) antiporters.
    2. results demonstrate that cysteines in the Sod2 protein can be changed to serine residues resulting in an expressed, functional protein
      Title: Functional role and analysis of cysteine residues of the salt tolerance protein Sod2.
    3. TM IV of Sod2 is critical to transport and may be involved in cation binding or conformational changes of the protein.
      Title: Structural and functional analysis of transmembrane segment IV of the salt tolerance protein Sod2.
    4. Role of nine polar, membrane associated amino acids in the ability of the protein to confer salt tolerance. The mutation P146A did not convey salt tolerance nearly as effectively as the wild type and did not extrude Na(+) as well as the wild type.
      Title: Proline 146 is critical to the structure, function and targeting of sod2, the Na+/H+ exchanger of Schizosaccharomyces pombe.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables sodium:proton antiporter activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables sodium:proton antiporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sodium:proton antiporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sodium:proton antiporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intracellular pH reduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular potassium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular sodium ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proton export across plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proton transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of membrane potential IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sodium ion export across plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sodium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nuclear outer membrane-endoplasmic reticulum membrane network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in perinuclear endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane of cell tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in prospore membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    plasma membrane/prospore membrane sodium ion/proton antiporter Nhe1/Sod2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      51989..53858
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001018182.4 → NP_592782.1  plasma membrane/prospore membrane sodium ion/proton antiporter Nhe1/Sod2 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_592782.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P36606
      Conserved Domains (1) summary
      COG0025
      Location:9 → 455
      NhaP; NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version

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