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    spo5 meiotic RNA-binding protein 1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2540637, updated on 18-Sep-2024

    Summary

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    Official Symbol
    spo5
    Official Full Name
    meiotic RNA-binding protein 1
    Primary source
    PomBase:SPBC29A10.02
    Locus tag
    SPOM_SPBC29A10.02
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    mrb1; mug12; SPBC365.18
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    Genomic context

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    See spo5 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    3
    Sequence:
    Chromosome: II; NC_003423.3 (2536150..2538254)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene NADPH-cytochrome p450 reductase Neighboring gene ncRNA Neighboring gene histone H3-H4 chaperone, CAF assembly factor (CAF-1) complex subunit A Pcf1 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Electron microscopic examination of sporulation-deficient mutants of the fission yeast Schizosaccharomyces pombe. Hirata A, et al. Arch Microbiol, 1992. PMID 1417417
    2. Spo5/Mug12, a putative meiosis-specific RNA-binding protein, is essential for meiotic progression and forms Mei2 dot-like nuclear foci. Kasama T, et al. Eukaryot Cell, 2006 Aug. PMID 16896214, Free PMC Article
    3. Spo5 phosphorylation is essential for its own timely degradation and for successful meiosis in Schizosaccharomyces pombe. Okuzaki D, et al. Cell Cycle, 2010 Sep 15. PMID 20855961
    4. Importin α and vNEBD Control Meiotic Spindle Disassembly in Fission Yeast. Flor-Parra I, et al. Cell Rep, 2018 Apr 24. PMID 29694900
    5. Functional significance of nuclear export and mRNA binding of meiotic regulator Spo5 in fission yeast. Togashi N, et al. BMC Microbiol, 2014 Jul 15. PMID 25023750, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Spo5 is exported from the nucleus with mRNAs via the Rae1-dependent pathway.
      Title: Functional significance of nuclear export and mRNA binding of meiotic regulator Spo5 in fission yeast.
    2. Spo5 is a novel regulator of meiosis II that controls the level of cdc13 expression and promotes de novo synthesis of Cdc13.
      Title: The RNA-binding protein Spo5 promotes meiosis II by regulating cyclin Cdc13 in fission yeast.
    3. The meiotic function of Spo5 is regulated by phosphorylation of the residues T29, T55, S59 and/or T63 and is required for the timely degradation of Spo5 during meiosis.
      Title: Spo5 phosphorylation is essential for its own timely degradation and for successful meiosis in Schizosaccharomyces pombe.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables poly(A) binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables poly(U) RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in ascospore formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ascospore-type prospore-specific spindle pole body remodeling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiosis I IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiosis II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nuclear membrane organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    meiotic RNA-binding protein 1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      2536150..2538254
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001021957.3 → NP_596047.1  meiotic RNA-binding protein 1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_596047.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O94381, Q2L4W6
      Conserved Domains (2) summary
      cd12243
      Location:296 → 366
      RRM1_MSSP; RNA recognition motif 1 in the c-myc gene single-strand binding proteins (MSSP) family
      cd12244
      Location:384 → 461
      RRM2_MSSP; RNA recognition motif 2 in the c-myc gene single-strand binding proteins (MSSP) family
    Nucleotide Protein
    Heading Accession and Version

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