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    rae1 nucleoporin Rae1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2539741, updated on 18-Sep-2024

    Summary

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    Official Symbol
    rae1
    Official Full Name
    nucleoporin Rae1
    Primary source
    PomBase:SPBC16A3.05c
    Locus tag
    SPOM_SPBC16A3.05C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    cut21
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    Genomic context

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    See rae1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    3
    Sequence:
    Chromosome: II; NC_003423.3 (4288945..4290900)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene protein nrm1 Neighboring gene tRNA specific adenosine deaminase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene mitochondrial 37S ribosomal protein mS23 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A mutation in the Schizosaccharomyces pombe rae1 gene causes defects in poly(A)+ RNA export and in the cytoskeleton. Brown JA, et al. J Biol Chem, 1995 Mar 31. PMID 7706287
    2. Npp106p, a Schizosaccharomyces pombe nucleoporin similar to Saccharomyces cerevisiae Nic96p, functionally interacts with Rae1p in mRNA export. Yoon JH, et al. Mol Cell Biol, 1997 Dec. PMID 9372936, Free PMC Article
    3. Advancement through mitosis requires rae1 gene function in fission yeast. Whalen WA, et al. Yeast, 1997 Sep 30. PMID 9301023
    4. The nuclear export signal of splicing factor Uap56p interacts with nuclear pore-associated protein Rae1p for mRNA export in Schizosaccharomyces pombe. Thakurta AG, et al. J Biol Chem, 2007 Jun 15. PMID 17449473
    5. Schizosaccharomyces pombe spPABP, a homologue of Saccharomyces cerevisiae Pab1p, is a non-essential, shuttling protein that facilitates mRNA export. Thakurta AG, et al. Yeast, 2002 Jun 30. PMID 12112233

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Nuclear accumulation of poly(A)(+) RNAs was detected in mutants of ago1(+) and ptr1(+), suggesting there is a functional link between the cell cycle checkpoint and RNAi-mediated RNA quality control.
      Title: RNA interference regulates the cell cycle checkpoint through the RNA export factor, Ptr1, in fission yeast.
    2. Data show that Uap56p interacts with Rae1p directly via its nuclear export signal, and this interaction is critical for the nuclear export activity of Uap56p as well as for exporting mRNA.
      Title: The nuclear export signal of splicing factor Uap56p interacts with nuclear pore-associated protein Rae1p for mRNA export in Schizosaccharomyces pombe.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA export from nucleus IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    NOT involved_in mitotic spindle assembly checkpoint signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in poly(A)+ mRNA export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosomal subunit export from nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nuclear envelope HDA PubMed 
    is_active_in nuclear periphery IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nuclear pore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    nucleoporin Rae1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      4288945..4290900
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001023805.3 → NP_596784.1  nucleoporin Rae1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_596784.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P41838
      Conserved Domains (3) summary
      COG2319
      Location:27 → 318
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:33 → 72
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:30 → 312
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version

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