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    srk1 MAPK-activated protein kinase Srk1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2539027, updated on 18-Sep-2024

    Summary

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    Official Symbol
    srk1
    Official Full Name
    MAPK-activated protein kinase Srk1
    Primary source
    PomBase:SPCC1322.08
    Locus tag
    SPOM_SPCC1322.08
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    mkp1
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    Genomic context

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    See srk1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    2
    Sequence:
    Chromosome: III; NC_003421.2 (1301937..1305468)

    Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene karyopherin/importin beta family nuclear import signal receptor Kap113 Neighboring gene ncRNA Neighboring gene protein mug150 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003421.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new negative feedback mechanism for MAPK pathway inactivation through Srk1 MAPKAP kinase. Marquina M, et al. Sci Rep, 2022 Nov 14. PMID 36376357, Free PMC Article
    2. A novel function of the mitochondrial transcription factor Mtf1 in fission yeast; Mtf1 regulates the nuclear transcription of srk1. Sun W, et al. Nucleic Acids Res, 2011 Apr. PMID 21138961, Free PMC Article
    3. The Srk1 protein kinase is a target for the Sty1 stress-activated MAPK in fission yeast. Smith DA, et al. J Biol Chem, 2002 Sep 6. PMID 12080074
    4. Mkp1 and Mkp2, two MAPKAP-kinase homologues in Schizosaccharomyces pombe, interact with the MAP kinase Sty1. Asp E, et al. Mol Genet Genomics, 2003 Feb. PMID 12589433
    5. Activation of Srk1 by the mitogen-activated protein kinase Sty1/Spc1 precedes its dissociation from the kinase and signals its degradation. López-Avilés S, et al. Mol Biol Cell, 2008 Apr. PMID 18272791, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A new negative feedback mechanism for MAPK pathway inactivation through Srk1 MAPKAP kinase.
      Title: A new negative feedback mechanism for MAPK pathway inactivation through Srk1 MAPKAP kinase.
    2. Ssp1 connects the network of components that ensures proper polarity and cell size with the network of proteins that regulates Cdk1-cyclin B activity, in which Srk1 plays an inhibitory role.
      Title: Ssp1 CaMKK: A Sensor of Actin Polarization That Controls Mitotic Commitment through Srk1 in Schizosaccharomyces pombe.
    3. Over expression of Mtf1 induced transcription of the srk1 gene and Mtf1 deletion led to a reduction in transcription of the srk1 gene in vivo.
      Title: A novel function of the mitochondrial transcription factor Mtf1 in fission yeast; Mtf1 regulates the nuclear transcription of srk1.
    4. In response to stress, Sty1/Spc1 phosphorylates Srk1 at threonine 463 of the regulatory domain, inducing both activation of Srk1 kinase, which negatively regulates cell cycle progression.
      Title: Activation of Srk1 by the mitogen-activated protein kinase Sty1/Spc1 precedes its dissociation from the kinase and signals its degradation.
    5. Srk1 controls mitotic entry by directly phosphorylating and inhibiting Cdc25 during a normal cell cycle and in response to osmotic stress.
      Title: Inactivation of the Cdc25 phosphatase by the stress-activated Srk1 kinase in fission yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables ATP binding ISM
    Inferred from Sequence Model
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to osmotic stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic DNA damage checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of G2/M transition of mitotic cell cycle IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of G2/M transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of induction of conjugation with cellular fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of protein localization to nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in ascospore-type prospore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    MAPK-activated protein kinase Srk1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003421.2 Reference assembly

      Range
      1301937..1305468
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001023126.3 → NP_588136.1  MAPK-activated protein kinase Srk1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_588136.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O94547
      Conserved Domains (2) summary
      smart00220
      Location:124 → 421
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14096
      Location:122 → 421
      STKc_RCK1-like; Catalytic domain of RCK1-like Serine/Threonine Kinases
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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    Research Materials