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    chp2 heterochromatin (HP1) family chromodomain protein Chp2 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2540047, updated on 14-Nov-2024

    Summary

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    Official Symbol
    chp2
    Official Full Name
    heterochromatin (HP1) family chromodomain protein Chp2
    Primary source
    PomBase:SPBC16C6.10
    Locus tag
    SPOM_SPBC16C6.10
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    clo2
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    Genomic context

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    See chp2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    2
    Sequence:
    Chromosome: II; NC_003423.3 (4349995..4351244)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ER membrane O-mannosyltransferase Ogm4 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene 60S ribosomal protein L32

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cooperative DNA-binding activities of Chp2 are critical for its function in heterochromatin assembly. Rahayu AF, et al. J Biochem, 2023 Sep 29. PMID 37400983
    2. The binding of Chp2's chromodomain to methylated H3K9 is essential for Chp2's role in heterochromatin assembly in fission yeast. Maksimov V, et al. PLoS One, 2018. PMID 30110338, Free PMC Article
    3. Diverse roles of HP1 proteins in heterochromatin assembly and functions in fission yeast. Fischer T, et al. Proc Natl Acad Sci U S A, 2009 Jun 2. PMID 19443688, Free PMC Article
    4. Transcriptional gene silencing requires dedicated interaction between HP1 protein Chp2 and chromatin remodeler Mit1. Leopold K, et al. Genes Dev, 2019 May 1. PMID 30808655, Free PMC Article
    5. Four chromo-domain proteins of Schizosaccharomyces pombe differentially repress transcription at various chromosomal locations. Thon G, et al. Genetics, 2000 Jun. PMID 10835380, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results suggest a two-step mechanism for SHREC's association with chromatin, in which Clr2 binds chromatin to form a platform for recruiting Clr1 and Clr3, while Chp2 may recruit Mit1 and additionally bind and stabilize the SHREC complex at the site. Stability of the Chp2 protein depended on the Clr3 protein's histone deacetylase activity.
      Title: The binding of Chp2's chromodomain to methylated H3K9 is essential for Chp2's role in heterochromatin assembly in fission yeast.
    2. findings uncover quantitative differences in how Swi6 and Chp2 interact with nucleosomal and non-nucleosomal ligands and qualitative differences in how their assembly on nucleosomes is regulated
      Title: Biochemical Basis for Distinct Roles of the Heterochromatin Proteins Swi6 and Chp2.
    3. Swi6 and Chp2 exist in nonoverlapping complexes and make distinct contributions to silencing.
      Title: HP1 proteins form distinct complexes and mediate heterochromatic gene silencing by nonoverlapping mechanisms.
    4. both Swi6 and Chp2 are required for the assembly of fully repressive heterochromatin, in which they play distinct, nonoverlapping roles
      Title: Balance between distinct HP1 family proteins controls heterochromatin assembly in fission yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone binding EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables methylated histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in heterochromatin formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in heterochromatin formation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in pericentric heterochromatin formation EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in pericentric heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rDNA heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulatory ncRNA-mediated heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in silent mating-type cassette heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in subtelomeric heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in mating-type region heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus HDA PubMed 
    located_in pericentric heterochromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in pericentric heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in subtelomeric heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    heterochromatin (HP1) family chromodomain protein Chp2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      4349995..4351244
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001023829.3 → NP_596808.1  heterochromatin (HP1) family chromodomain protein Chp2 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_596808.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O42934
      Conserved Domains (2) summary
      smart00300
      Location:316 → 380
      ChSh; Chromo Shadow Domain
      cd00024
      Location:174 → 228
      CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
    Nucleotide Protein
    Heading Accession and Version

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