F10 coagulation factor X [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: F10provided by MGI
Official Full Name: coagulation factor Xprovided by MGI
Primary source: MGI:MGI:103107
See related: Ensembl:ENSMUSG00000031444 AllianceGenome:MGI:103107
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: fX; Cf10
Summary: This gene encodes factor X, a component of both the intrinsic and extrinsic blood coagulation pathways. The encoded protein is a zymogen that undergoes further processing in a vitamin K-dependent manner to generate mature factor X, a heterodimer comprised of disulfide-linked heavy and light chains. The mature factor X is proteolytically activated either by factor IXa (intrinsic pathway) or factor VIIa (extrinsic pathway) to form factor Xa serine endopeptidase. Activated factor Xa catalyzes the conversion of prothrombin to thrombin. A complete lack of the encoded protein is fatal to mice. A severe deficiency of the encoded protein in mice causes age-dependent iron deposition and cardiac fibrosis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]
Expression: Biased expression in liver E18 (RPKM 103.5), liver adult (RPKM 83.2) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 A1.1; 8 5.73 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (13087308..13106676)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (13037308..13056676)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Intrinsic Expression of Coagulation Factors and Protease Activated Receptor 1 (PAR1) in Photoreceptors and Inner Retinal Layers.
Title: Intrinsic Expression of Coagulation Factors and Protease Activated Receptor 1 (PAR1) in Photoreceptors and Inner Retinal Layers.
PTX2 was identified PTX2 as a novel partner for FX, and both proteins cooperated to prevent their SR-AI-mediated uptake by macrophages.
Title: Complex formation with pentraxin-2 regulates factor X plasma levels and macrophage interactions.
annexin A2 contributes to lung injury and fibrotic disease by mediating the fibrogenic actions of FXa.
Title: Annexin A2 contributes to lung injury and fibrosis by augmenting factor Xa fibrogenic activity.
Enhanced FXa and PAR2 exacerbate DN and that both are promising targets for preventing diabetic nephropathy.
Title: Coagulation Factor Xa and Protease-Activated Receptor 2 as Novel Therapeutic Targets for Diabetic Nephropathy.
Macrophages regulate FX plasma levels in an SR-AI-dependent manner.
Title: Macrophage receptor SR-AI is crucial to maintain normal plasma levels of coagulation factor X.
Factor Xa has a role in inhibiting HMGB1-induced septic responses in human umbilical vein endothelial cells and in mice
Title: Factor Xa inhibits HMGB1-induced septic responses in human umbilical vein endothelial cells and in mice.
Selective inhibition of FXa improves the left ventricular function during CVB3-induced myocarditis and seems to be associated with an improved myocardial remodeling.
Title: Inhibition of coagulation factor Xa improves myocardial function during CVB3-induced myocarditis.
Activated factor X signaling via protease-activated receptor 2 suppresses pro-inflammatory cytokine production from lipopolysaccharide-stimulated myeloid cells.
Title: Activated factor X signaling via protease-activated receptor 2 suppresses pro-inflammatory cytokine production from lipopolysaccharide-stimulated myeloid cells.
Differential effects of murine and human factor X on adenovirus transduction via cell-surface heparan sulfate.
Title: Differential effects of murine and human factor X on adenovirus transduction via cell-surface heparan sulfate.
There was no detectable increase in plasma levels of mouse FX after active-site inhibited human APC administration to mice overexpressing human EPCR. FX does not effectively interact with EPCR in vivo, at least in regards to the mouse system.
Title: Factor X binding to endothelial cell protein C receptor: comparison with factor VIIa and activated protein C.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F10 (e-PCR), detects polymorphism
- UniSTS:525901

F7 (e-PCR), detects polymorphism
- UniSTS:525909

F7 (e-PCR), detects polymorphism
- UniSTS:143056

AI132620 (e-PCR)
- UniSTS:159737

AI194738 (e-PCR)
- UniSTS:159740

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables phospholipid binding	ISO Inferred from Sequence Orthology more info
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in blood coagulation	IBA Inferred from Biological aspect of Ancestor more info
involved_in blood coagulation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of TOR signaling	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: coagulation factor X

Names: stuart factor

NP_001229297.1

EC 3.4.21.6

NP_031998.3

EC 3.4.21.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001242368.1 → NP_001229297.1 coagulation factor X isoform 1 precursor

See identical proteins and their annotated locations for NP_001229297.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC127308, BC050219

Consensus CDS

CCDS57606.1

UniProtKB/TrEMBL

Q3TDB9, Q3U3V1

Related

ENSMUSP00000033821.5, ENSMUST00000033821.11

Conserved Domains (5) summary

smart00020
Location:243 → 471

Tryp_SPc; Trypsin-like serine protease

smart00069
Location:36 → 97

GLA; Domain containing Gla (gamma-carboxyglutamate) residues

cd00054
Location:98 → 134

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00190
Location:244 → 473

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

pfam14670
Location:141 → 176

FXa_inhibition; Coagulation Factor Xa inhibitory site
NM_007972.4 → NP_031998.3 coagulation factor X isoform 2 preproprotein

See identical proteins and their annotated locations for NP_031998.3

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream, in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AC127308, AF087644

Consensus CDS

CCDS40226.1

UniProtKB/Swiss-Prot

O54740, O88947, Q99L32

UniProtKB/TrEMBL

Q3TBR2, Q4FJS7

Related

ENSMUSP00000068389.6, ENSMUST00000063820.12

Conserved Domains (5) summary

smart00020
Location:231 → 459

Tryp_SPc; Trypsin-like serine protease

smart00069
Location:24 → 85

GLA; Domain containing Gla (gamma-carboxyglutamate) residues

cd00054
Location:86 → 122

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00190
Location:232 → 461

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

pfam14670
Location:129 → 164

FXa_inhibition; Coagulation Factor Xa inhibitory site