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    Krt80 keratin 80 [ Mus musculus (house mouse) ]

    Gene ID: 74127, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Krt80provided by MGI
    Official Full Name
    keratin 80provided by MGI
    Primary source
    MGI:MGI:1921377
    See related
    Ensembl:ENSMUSG00000037185 AllianceGenome:MGI:1921377
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    K80; Kb20; CK-80; 1200016G03Rik; 2310041I20Rik
    Summary
    Predicted to be a structural constituent of skin epidermis. Predicted to be involved in intermediate filament organization and keratinization. Predicted to be located in cytoplasm and intermediate filament. Predicted to be active in keratin filament. Is expressed in molar; naris; renal calyx; submandibular gland primordium; and vibrissa. Orthologous to human KRT80 (keratin 80). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in lung adult (RPKM 47.4), stomach adult (RPKM 18.2) and 4 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Krt80 in Genome Data Viewer
    Location:
    15 F1; 15 56.78 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (101246196..101268043, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (101348315..101370162, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene small integral membrane protein 41 Neighboring gene predicted gene, 41403 Neighboring gene predicted gene, 52200 Neighboring gene predicted gene, 35853 Neighboring gene microRNA 1941 Neighboring gene predicted gene 671 Neighboring gene STARR-seq mESC enhancer starr_39796 Neighboring gene keratin 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Increased B lymphopoiesis in genetically sex steroid-deficient hypogonadal (hpg) mice. Smithson G, et al. J Exp Med, 1994 Aug 1. PMID 8046347, Free PMC Article
    2. Complete Structure of an Epithelial Keratin Dimer: Implications for Intermediate Filament Assembly. Bray DJ, et al. PLoS One, 2015. PMID 26181054, Free PMC Article
    3. Tracing the origin of hair follicle stem cells. Morita R, et al. Nature, 2021 Jun. PMID 34108685
    4. New consensus nomenclature for mammalian keratins. Schweizer J, et al. J Cell Biol, 2006 Jul 17. PMID 16831889, Free PMC Article
    5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables structural constituent of skin epidermis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in intermediate filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in keratinization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intermediate filament ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intermediate filament cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in keratin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in keratin filament NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    keratin, type II cytoskeletal 80
    Names
    cytokeratin-80
    type-II keratin Kb20

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028770.3 → NP_083046.2  keratin, type II cytoskeletal 80

      See identical proteins and their annotated locations for NP_083046.2

      Status: VALIDATED

      Source sequence(s)
      AC163018, AK004811, BB843716, BC120601
      Consensus CDS
      CCDS37216.1
      UniProtKB/Swiss-Prot
      Q0VBK2
      Related
      ENSMUSP00000076437.5, ENSMUST00000077196.6
      Conserved Domains (2) summary
      pfam00038
      Location:82 → 393
      Filament; Intermediate filament protein
      pfam16208
      Location:9 → 78
      Keratin_2_head; Keratin type II head

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      101246196..101268043 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006521487.4 → XP_006521550.1  keratin, type II cytoskeletal 80 isoform X1

      UniProtKB/TrEMBL
      Q3TBQ1
      Conserved Domains (1) summary
      pfam00038
      Location:1 → 178
      Filament; Intermediate filament protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0VBK2.1 GenPept UniProtKB/Swiss-Prot:Q0VBK2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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