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    ZBTB26 zinc finger and BTB domain containing 26 [ Homo sapiens (human) ]

    Gene ID: 57684, updated on 10-Dec-2024

    Summary

    Official Symbol
    ZBTB26provided by HGNC
    Official Full Name
    zinc finger and BTB domain containing 26provided by HGNC
    Primary source
    HGNC:HGNC:23383
    See related
    Ensembl:ENSG00000171448 MIM:620164; AllianceGenome:HGNC:23383
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZNF481; bioref
    Summary
    Enables identical protein binding activity and sequence-specific double-stranded DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; regulation of cytokine production; and regulation of immune system process. Predicted to be located in nucleus. Predicted to be active in nucleoplasm. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis (RPKM 7.0), ovary (RPKM 4.9) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See ZBTB26 in Genome Data Viewer
    Location:
    9q33.2
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (122915566..122931512, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (135112805..135128757, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (125677845..125693791, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene ring finger and CCCH-type domains 2 Neighboring gene small nucleolar RNA, C/D box 90 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20243 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28929 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28930 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:125677135-125677892 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:125683768-125684268 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:125684269-125684769 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20244 Neighboring gene zinc finger and BTB domain containing 6 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28931 Neighboring gene uncharacterized LOC105379839 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:125703098-125703822 Neighboring gene RAB GTPase activating protein 1 Neighboring gene RNY1 pseudogene 15

    Genomic regions, transcripts, and products

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Potential readthrough

    Included gene: ZBTB6

    Clone Names

    • KIAA1572

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables sequence-specific double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of cytokine production IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of immune system process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    zinc finger and BTB domain-containing protein 26
    Names
    zinc finger protein 481
    zinc finger protein 483
    zinc finger protein Bioref

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001304363.2 → NP_001291292.1  zinc finger and BTB domain-containing protein 26

      See identical proteins and their annotated locations for NP_001291292.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate splice site in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC007066, AK058083, BC018748, BM682342, DA212731
      Consensus CDS
      CCDS6847.1
      UniProtKB/Swiss-Prot
      B3KQ53, Q8WTR1, Q9HCK0
      Conserved Domains (5) summary
      COG5236
      Location:269 → 381
      COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
      sd00017
      Location:300 → 320
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18214
      Location:8 → 129
      BTB_POZ_ZBTB26_Bioref; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 26 (ZBTB26)
      pfam00096
      Location:298 → 320
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:315 → 337
      zf-H2C2_2; Zinc-finger double domain
    2. NM_001304364.2 → NP_001291293.1  zinc finger and BTB domain-containing protein 26

      See identical proteins and their annotated locations for NP_001291293.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has an alternate 5' UTR exon, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC007066, AK057445, AK058083, BM682342
      Consensus CDS
      CCDS6847.1
      UniProtKB/Swiss-Prot
      B3KQ53, Q8WTR1, Q9HCK0
      Related
      ENSP00000362758.1, ENST00000373654.1
      Conserved Domains (5) summary
      COG5236
      Location:269 → 381
      COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
      sd00017
      Location:300 → 320
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18214
      Location:8 → 129
      BTB_POZ_ZBTB26_Bioref; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 26 (ZBTB26)
      pfam00096
      Location:298 → 320
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:315 → 337
      zf-H2C2_2; Zinc-finger double domain
    3. NM_020924.4 → NP_065975.1  zinc finger and BTB domain-containing protein 26

      See identical proteins and their annotated locations for NP_065975.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) and variants 2 and 3 encode the same protein.
      Source sequence(s)
      AC007066, AK058083, BC018748, BM682342, HY066289
      Consensus CDS
      CCDS6847.1
      UniProtKB/Swiss-Prot
      B3KQ53, Q8WTR1, Q9HCK0
      Related
      ENSP00000362760.3, ENST00000373656.4
      Conserved Domains (5) summary
      COG5236
      Location:269 → 381
      COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
      sd00017
      Location:300 → 320
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18214
      Location:8 → 129
      BTB_POZ_ZBTB26_Bioref; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 26 (ZBTB26)
      pfam00096
      Location:298 → 320
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:315 → 337
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      122915566..122931512 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      135112805..135128757 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)