MYCNOS MYCN opposite strand [Homo sapiens (human)] - Gene

Summary

Official Symbol: MYCNOSprovided by HGNC
Official Full Name: MYCN opposite strandprovided by HGNC
Primary source: HGNC:HGNC:16911
See related: Ensembl:ENSG00000233718 MIM:605374; AllianceGenome:HGNC:16911
Gene type: ncRNA
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: NCYM; NYCM; N-CYM; MYCN-AS1
Summary: This gene is transcribed in antisense to the v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog gene (MYCN). It is thought to encode a small, novel protein that stabilizes MYCN, prevents apoptosis, and promotes cell proliferation. Transcripts at this locus may also act directly as functional RNAs to recruit transcriptional regulators to the promoter of MYCN and stimulate transcription of this oncogene. This gene therefore functions through both RNA and protein products. [provided by RefSeq, Aug 2016]
Expression: Low expression observed in reference dataset See more
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 2p24.3

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	2	NC_000002.12 (15936265..15942433, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	2	NC_060926.1 (15967896..15974065, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (16076387..16082555, complement)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

De novo evolved gene product NCYM in the pathogenesis and clinical outcome of human neuroblastomas and other cancers.
Title: De novo evolved gene product NCYM in the pathogenesis and clinical outcome of human neuroblastomas and other cancers.
Expression levels of TAp63mRNA inversely correlated with those of MYCN/NCYM expression in primary neuroblastomas, which was associated with a favorable prognosis.
Title: TAp63 represses transcription of MYCN/NCYM gene and its high levels of expression are associated with favorable outcome in neuroblastoma.
Results suggest that concomitant overexpression of MYCN and MYCNOS may be a general phenomenon in pediatric hepatoblastoma (HB) tumors, especially in those with more undifferentiated histology. Hypomethylation of the MYCN/MYCNOS locus is associated with high expression levels.
Title: Targeting excessive MYCN expression using MLN8237 and JQ1 impairs the growth of hepatoblastoma cells.
lncRNA long stress-induced noncoding transcript 5 (LSINCT5) is significantly upregulated in human bladder cancer cell lines and tumor specimens. Mechanistic investigations showed that LSINCT5 could physically interact with NCYM, a de novo gene product from the MYCN cis-antisense RNA and inhibit GSK3beta activity leading to enhanced Wnt/beta-catenin signaling activation and epithelial mesenchymal transition (EMT).
Title: LSINCT5 activates Wnt/β-catenin signaling by interacting with NCYM to promote bladder cancer progression.
An alternative transcript of MYCNOS, MYCNOS-01, post-transcriptionally regulates MYCN levels and affects growth in MYCN-amplified rhabdomyosarcoma and neuroblastoma cells.
Title: The long non-coding RNA MYCNOS-01 regulates MYCN protein levels and affects growth of MYCN-amplified rhabdomyosarcoma and neuroblastoma cells.
High levels of NCYM expression in human neuroblastoma tissues correlate with high levels of N-Myc, NonO and lncUSMycN expression and poor patient survival, and treatment with BET bromodomain inhibitors reduces NCYM expression, providing further evidence for the application of BET bromodomain inhibitors for the therapy of neuroblastoma characterized by MYCN/NCYM gene locus amplification.
Title: NCYM is upregulated by lncUSMycN and modulates N-Myc expression.
functional interplay between MYCN, NCYM, and OCT4 contributes to aggressiveness of MYCN-amplified human neuroblastomas.
Title: Functional interplay between MYCN, NCYM, and OCT4 promotes aggressiveness of human neuroblastomas.
these results suggest that GSK3b inhibition by NCYM stabilizes the MYCN protein both in vitro and in vivo.
Title: NCYM, a Cis-antisense gene of MYCN, encodes a de novo evolved protein that inhibits GSK3β resulting in the stabilization of MYCN in human neuroblastomas.

Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

Go to the top of the page Help

Markers

D11S2921 (e-PCR)
- UniSTS:152074

MYCN (e-PCR)
- UniSTS:266043

RH17899 (e-PCR)
- UniSTS:32360

Other Names

DNA-binding transcriptional activator NCYM
MYCN antisense RNA 1
MYCN opposite strand/antisense RNA (non-protein coding)
N-myc opposite strand
v-myc myelocytomatosis viral related oncogene, neuroblastoma derived opposite strand

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of kinase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of protein stability	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

NR_110230.2 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC010145

Related

ENST00000641263.1
NR_161162.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC010145, KF456635
NR_161163.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC010145, KF456635

Related

ENST00000641534.2