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    Cped1 cadherin-like and PC-esterase domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 214642, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Cped1provided by MGI
    Official Full Name
    cadherin-like and PC-esterase domain containing 1provided by MGI
    Primary source
    MGI:MGI:2444814
    See related
    Ensembl:ENSMUSG00000062980 AllianceGenome:MGI:2444814
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    6720481P07; A430107O13Rik
    Summary
    Predicted to be located in endoplasmic reticulum. Is expressed in several structures, including gut; limb segment; lung; meninges; and skin. Orthologous to human CPED1 (cadherin like and PC-esterase domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in subcutaneous fat pad adult (RPKM 13.7), bladder adult (RPKM 10.2) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cped1 in Genome Data Viewer
    Location:
    6 A3.1; 6 8.86 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (21985875..22256406)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (21985710..22256407)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene tetraspanin 12 Neighboring gene predicted gene, 30270 Neighboring gene STARR-positive B cell enhancer ABC_E676 Neighboring gene STARR-positive B cell enhancer ABC_E6418 Neighboring gene inhibitor of growth family, member 3 Neighboring gene STARR-seq mESC enhancer starr_15304 Neighboring gene STARR-seq mESC enhancer starr_15305 Neighboring gene STARR-seq mESC enhancer starr_15306 Neighboring gene STARR-seq mESC enhancer starr_15307 Neighboring gene STARR-seq mESC enhancer starr_15308 Neighboring gene 60S ribosomal protein L32 pseudogene Neighboring gene STARR-seq mESC enhancer starr_15309 Neighboring gene predicted gene 42573 Neighboring gene STARR-seq mESC enhancer starr_15310 Neighboring gene wingless-type MMTV integration site family, member 16 Neighboring gene FAM3 metabolism regulating signaling molecule C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Multiple Mechanisms Explain Genetic Effects at the CPED1-WNT16 Bone Mineral Density Locus. Gómez AE, et al. Curr Osteoporos Rep, 2023 Apr. PMID 36943599, Free PMC Article
    2. Characterization of expression and alternative splicing of the gene cadherin-like and PC esterase domain containing 1 (Cped1). Maynard RD, et al. Gene, 2018 Oct 20. PMID 29935354, Free PMC Article
    3. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Multiple Mechanisms Explain Genetic Effects at the CPED1-WNT16 Bone Mineral Density Locus.
      Title: Multiple Mechanisms Explain Genetic Effects at the CPED1-WNT16 Bone Mineral Density Locus.
    2. Some of the first data describing expression and alternative splicing of Cped1.
      Title: Characterization of expression and alternative splicing of the gene cadherin-like and PC esterase domain containing 1 (Cped1).
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cadherin-like and PC-esterase domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081351.2 → NP_001074820.1  cadherin-like and PC-esterase domain-containing protein 1 isoform a

      See identical proteins and their annotated locations for NP_001074820.1

      Status: VALIDATED

      Source sequence(s)
      AC115039, AC117213, AC133955
      Consensus CDS
      CCDS39435.1
      UniProtKB/TrEMBL
      A0A2Z4MSH0, B2RX70
      Related
      ENSMUSP00000111041.3, ENSMUST00000115383.9
      Conserved Domains (1) summary
      pfam12733
      Location:578 → 663
      Cadherin-like; Cadherin-like beta sandwich domain

    2. NM_001418022.1 → NP_001404951.1  cadherin-like and PC-esterase domain-containing protein 1 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC115039, AC117213, AC133955
      UniProtKB/TrEMBL
      B2RX70

    3. NM_001418023.1 → NP_001404952.1  cadherin-like and PC-esterase domain-containing protein 1 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC117213, AC133955

    4. NM_001418024.1 → NP_001404953.1  cadherin-like and PC-esterase domain-containing protein 1 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC115039, AC117213, AC133955
      UniProtKB/TrEMBL
      A0A2Z4MSG2

    5. NM_001418025.1 → NP_001404954.1  cadherin-like and PC-esterase domain-containing protein 1 isoform d

      Status: VALIDATED

      Source sequence(s)
      AC115039, AC117213, AC133955
      Related
      ENSMUSP00000119808.3, ENSMUST00000137437.6

    6. NM_001418026.1 → NP_001404955.1  cadherin-like and PC-esterase domain-containing protein 1 isoform e

      Status: VALIDATED

      Source sequence(s)
      AC117213, AC133955

    7. NM_001418027.1 → NP_001404956.1  cadherin-like and PC-esterase domain-containing protein 1 isoform f

      Status: VALIDATED

      Source sequence(s)
      AC117213, AC133955

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      21985875..22256406
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036166012.1 → XP_036021905.1  cadherin-like and PC-esterase domain-containing protein 1 isoform X4

      Conserved Domains (1) summary
      pfam12733
      Location:577 → 663
      Cadherin-like; Cadherin-like beta sandwich domain

    2. XM_006505040.5 → XP_006505103.1  cadherin-like and PC-esterase domain-containing protein 1 isoform X3

      Conserved Domains (1) summary
      pfam12733
      Location:578 → 663
      Cadherin-like; Cadherin-like beta sandwich domain

    3. XM_006505042.5 → XP_006505105.1  cadherin-like and PC-esterase domain-containing protein 1 isoform X5

      UniProtKB/TrEMBL
      Q8BMB4
      Conserved Domains (1) summary
      pfam12733
      Location:270 → 355
      Cadherin-like; Cadherin-like beta sandwich domain

    RNA

    1. XR_004942929.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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