Aasdh aminoadipate-semialdehyde dehydrogenase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Aasdhprovided by MGI
Official Full Name: aminoadipate-semialdehyde dehydrogenaseprovided by MGI
Primary source: MGI:MGI:2442517
See related: Ensembl:ENSMUSG00000055923 AllianceGenome:MGI:2442517
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: U26; Acsf4; A830035E16; A230062G08Rik
Summary: The gene product is a cytosolic enzyme involved in the production of alpha-aminoadipic acid from alpha-aminoadipic semialdehyde. It is postulated that this enzyme plays a role in lysine metabolism. There is currently debate regarding this enzyme's putative requirement of pyrroloquinoline quinine as an essential cofactor. A related pseudogene has been identified on chromosome 2. [provided by RefSeq, Jan 2010]
Expression: Ubiquitous expression in bladder adult (RPKM 4.3), CNS E14 (RPKM 3.1) and 28 other tissues See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 5 C3.3; 5 41.45 cM

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (77021506..77053376, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (76873659..76905529, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Recombinant ACSF4-U26 progressively formed a covalent bond with radiolabelled beta-alanine. The bond was not formed in a point mutant lacking the phosphopantetheine attachment site.
Title: Vertebrate Acyl CoA synthetase family member 4 (ACSF4-U26) is a β-alanine-activating enzyme homologous to bacterial non-ribosomal peptide synthetase.
ACSF4 (U26) is a beta-alanine activating enzyme homologous to bacterial nonribosomal peptide synthetase. Experiments using the mouse protein suggest this enzyme may be involved in a rare intracellular reaction, possibly an infrequent post-translational or post-transcriptional modification.
Title: Vertebrate Acyl CoA synthetase family member 4 (ACSF4-U26) is a β-alanine-activating enzyme homologous to bacterial non-ribosomal peptide synthetase.
involved in the lysine degradation pathway
Title: Nutritional biochemistry: A new redox-cofactor vitamin for mammals.

Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (1)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

AI507113 (e-PCR)
- UniSTS:165403

RH124742 (e-PCR)
- UniSTS:161564

D5Mit306 (e-PCR), detects polymorphism
- UniSTS:130447

RH126767 (e-PCR)
- UniSTS:207813

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables acid-thiol ligase activity	ISS Inferred from Sequence or Structural Similarity more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in amino acid activation for nonribosomal peptide biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within amino acid activation for nonribosomal peptide biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within beta-alanine metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in fatty acid metabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info

General protein information

Go to the top of the page Help

Preferred Names: beta-alanine-activating enzyme

Names: 2-aminoadipic 6-semialdehyde dehydrogenase; acyl-CoA synthetase family member 4; protein LYS2 homolog; putative aminoadipate-semialdehyde dehydrogenase

NP_001363933.1

EC 6.2.1.-

NP_776126.1

EC 6.2.1.-

XP_006534916.1

EC 6.2.1.-

XP_006534917.1

EC 6.2.1.-

XP_006534919.1

EC 6.2.1.-

XP_006534920.1

EC 6.2.1.-

XP_006534922.1

EC 6.2.1.-

XP_006534923.1

EC 6.2.1.-

XP_011247724.1

EC 6.2.1.-

XP_011247725.1

EC 6.2.1.-

XP_017176330.1

EC 6.2.1.-

XP_030110250.1

EC 6.2.1.-

XP_030110251.1

EC 6.2.1.-

XP_030110252.1

EC 6.2.1.-

XP_036020953.1

EC 6.2.1.-

XP_036020954.1

EC 6.2.1.-

XP_036020955.1

EC 6.2.1.-

XP_036020956.1

EC 6.2.1.-

XP_036020957.1

EC 6.2.1.-

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001377004.1 → NP_001363933.1 beta-alanine-activating enzyme

Status: REVIEWED

Description

Transcript Variant: Variants 1 and 2 encode the same protein.

Source sequence(s)

AC114666, AC166328

UniProtKB/Swiss-Prot

Q3V3L2, Q505K4, Q80WC9, Q8BRP4

Conserved Domains (4) summary

COG1520
Location:754 → 986

PQQ; Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis]

TIGR03300
Location:923 → 1094

assembly_YfgL; outer membrane assembly lipoprotein YfgL

cd17654
Location:15 → 532

A_NRPS_acs4; acyl-CoA synthetase family member 4

pfam00550
Location:561 → 628

PP-binding; Phosphopantetheine attachment site
NM_173765.4 → NP_776126.1 beta-alanine-activating enzyme

See identical proteins and their annotated locations for NP_776126.1

Status: REVIEWED

Description

Transcript Variant: Variants 1 and 2 encode the same protein.

Source sequence(s)

AC114666, AC166328

Consensus CDS

CCDS19366.1

UniProtKB/Swiss-Prot

Q3V3L2, Q505K4, Q80WC9, Q8BRP4

Related

ENSMUSP00000113792.2, ENSMUST00000120963.8

Conserved Domains (4) summary

COG1520
Location:754 → 986

PQQ; Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis]

TIGR03300
Location:923 → 1094

assembly_YfgL; outer membrane assembly lipoprotein YfgL

cd17654
Location:15 → 532

A_NRPS_acs4; acyl-CoA synthetase family member 4

pfam00550
Location:561 → 628

PP-binding; Phosphopantetheine attachment site

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

77021506..77053376 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006534854.3 → XP_006534917.1 beta-alanine-activating enzyme isoform X2

Conserved Domains (4) summary

COG1520
Location:754 → 1051

PQQ; Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis]

sd00039
Location:815 → 849

7WD40; WD40 repeat [structural motif]

cd17654
Location:15 → 532

A_NRPS_acs4; acyl-CoA synthetase family member 4

pfam00550
Location:561 → 628

PP-binding; Phosphopantetheine attachment site
XM_011249423.3 → XP_011247725.1 beta-alanine-activating enzyme isoform X4

Conserved Domains (4) summary

TIGR03300
Location:730 → 881

assembly_YfgL; outer membrane assembly lipoprotein YfgL

sd00039
Location:816 → 850

7WD40; WD40 repeat [structural motif]

cd17654
Location:15 → 532

A_NRPS_acs4; acyl-CoA synthetase family member 4

pfam00550
Location:561 → 628

PP-binding; Phosphopantetheine attachment site
XM_006534856.4 → XP_006534919.1 beta-alanine-activating enzyme isoform X5

Conserved Domains (4) summary

TIGR03300
Location:730 → 881

assembly_YfgL; outer membrane assembly lipoprotein YfgL

sd00039
Location:816 → 850

7WD40; WD40 repeat [structural motif]

cd17654
Location:15 → 532

A_NRPS_acs4; acyl-CoA synthetase family member 4

pfam00550
Location:561 → 628

PP-binding; Phosphopantetheine attachment site
XM_006534857.4 → XP_006534920.1 beta-alanine-activating enzyme isoform X6

Conserved Domains (4) summary

COG1520
Location:592 → 824

PQQ; Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis]

TIGR03300
Location:761 → 932

assembly_YfgL; outer membrane assembly lipoprotein YfgL

cd17654
Location:26 → 370

A_NRPS_acs4; acyl-CoA synthetase family member 4

pfam00550
Location:399 → 448

PP-binding; Phosphopantetheine attachment site
XM_036165061.1 → XP_036020954.1 beta-alanine-activating enzyme isoform X8

Conserved Domains (4) summary

COG1520
Location:569 → 866

PQQ; Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis]

sd00039
Location:630 → 664

7WD40; WD40 repeat [structural motif]

cd17654
Location:34 → 347

A_NRPS_acs4; acyl-CoA synthetase family member 4

pfam00550
Location:376 → 425

PP-binding; Phosphopantetheine attachment site
XM_030254392.1 → XP_030110252.1 beta-alanine-activating enzyme isoform X7

Conserved Domains (4) summary

COG1520
Location:569 → 801

PQQ; Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis]

TIGR03300
Location:738 → 909

assembly_YfgL; outer membrane assembly lipoprotein YfgL

cd17654
Location:34 → 347

A_NRPS_acs4; acyl-CoA synthetase family member 4

pfam00550
Location:376 → 443

PP-binding; Phosphopantetheine attachment site
XM_006534853.3 → XP_006534916.1 beta-alanine-activating enzyme isoform X1

See identical proteins and their annotated locations for XP_006534916.1

UniProtKB/Swiss-Prot

Q3V3L2, Q505K4, Q80WC9, Q8BRP4

Related

ENSMUSP00000069279.9, ENSMUST00000069709.15

Conserved Domains (4) summary

COG1520
Location:754 → 986

PQQ; Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis]

TIGR03300
Location:923 → 1094

assembly_YfgL; outer membrane assembly lipoprotein YfgL

cd17654
Location:15 → 532

A_NRPS_acs4; acyl-CoA synthetase family member 4

pfam00550
Location:561 → 628

PP-binding; Phosphopantetheine attachment site
XM_011249422.2 → XP_011247724.1 beta-alanine-activating enzyme isoform X1

See identical proteins and their annotated locations for XP_011247724.1

UniProtKB/Swiss-Prot

Q3V3L2, Q505K4, Q80WC9, Q8BRP4

Conserved Domains (4) summary

COG1520
Location:754 → 986

PQQ; Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis]

TIGR03300
Location:923 → 1094

assembly_YfgL; outer membrane assembly lipoprotein YfgL

cd17654
Location:15 → 532

A_NRPS_acs4; acyl-CoA synthetase family member 4

pfam00550
Location:561 → 628

PP-binding; Phosphopantetheine attachment site
XM_036165060.1 → XP_036020953.1 beta-alanine-activating enzyme isoform X6

Conserved Domains (4) summary

COG1520
Location:592 → 824

PQQ; Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis]

TIGR03300
Location:761 → 932

assembly_YfgL; outer membrane assembly lipoprotein YfgL

cd17654
Location:26 → 370

A_NRPS_acs4; acyl-CoA synthetase family member 4

pfam00550
Location:399 → 448

PP-binding; Phosphopantetheine attachment site
XM_030254390.1 → XP_030110250.1 beta-alanine-activating enzyme isoform X2

Conserved Domains (4) summary

COG1520
Location:754 → 1051

PQQ; Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis]

sd00039
Location:815 → 849

7WD40; WD40 repeat [structural motif]

cd17654
Location:15 → 532

A_NRPS_acs4; acyl-CoA synthetase family member 4

pfam00550
Location:561 → 628

PP-binding; Phosphopantetheine attachment site
XM_036165063.1 → XP_036020956.1 beta-alanine-activating enzyme isoform X12

Conserved Domains (3) summary

COG1520
Location:242 → 474

PQQ; Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis]

TIGR03300
Location:411 → 582

assembly_YfgL; outer membrane assembly lipoprotein YfgL

pfam00550
Location:49 → 98

PP-binding; Phosphopantetheine attachment site
XM_030254391.1 → XP_030110251.1 beta-alanine-activating enzyme isoform X6

Conserved Domains (4) summary

COG1520
Location:592 → 824

PQQ; Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis]

TIGR03300
Location:761 → 932

assembly_YfgL; outer membrane assembly lipoprotein YfgL

cd17654
Location:26 → 370

A_NRPS_acs4; acyl-CoA synthetase family member 4

pfam00550
Location:399 → 448

PP-binding; Phosphopantetheine attachment site
XM_036165064.1 → XP_036020957.1 beta-alanine-activating enzyme isoform X12

Conserved Domains (3) summary

COG1520
Location:242 → 474

PQQ; Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis]

TIGR03300
Location:411 → 582

assembly_YfgL; outer membrane assembly lipoprotein YfgL

pfam00550
Location:49 → 98

PP-binding; Phosphopantetheine attachment site
XM_006534860.4 → XP_006534923.1 beta-alanine-activating enzyme isoform X10

Conserved Domains (4) summary

COG1520
Location:392 → 624

PQQ; Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis]

TIGR03300
Location:561 → 732

assembly_YfgL; outer membrane assembly lipoprotein YfgL

pfam00550
Location:199 → 266

PP-binding; Phosphopantetheine attachment site

cl17068
Location:4 → 170

AFD_class_I; Adenylate forming domain, Class I superfamily
XM_036165062.1 → XP_036020955.1 beta-alanine-activating enzyme isoform X11

Conserved Domains (4) summary

COG1520
Location:392 → 689

PQQ; Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis]

sd00039
Location:453 → 487

7WD40; WD40 repeat [structural motif]

pfam00550
Location:199 → 248

PP-binding; Phosphopantetheine attachment site

cl17068
Location:4 → 170

AFD_class_I; Adenylate forming domain, Class I superfamily
XM_017320841.3 → XP_017176330.1 beta-alanine-activating enzyme isoform X3

Conserved Domains (3) summary

COG1520
Location:754 → 962

PQQ; Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis]

cd17654
Location:15 → 532

A_NRPS_acs4; acyl-CoA synthetase family member 4

pfam00550
Location:561 → 628

PP-binding; Phosphopantetheine attachment site
XM_006534859.5 → XP_006534922.1 beta-alanine-activating enzyme isoform X9

Conserved Domains (3) summary

COG1520
Location:592 → 800

PQQ; Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis]

cd17654
Location:26 → 370

A_NRPS_acs4; acyl-CoA synthetase family member 4

pfam00550
Location:399 → 466

PP-binding; Phosphopantetheine attachment site