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    Ccl24 C-C motif chemokine ligand 24 [ Mus musculus (house mouse) ]

    Gene ID: 56221, updated on 13-Jan-2025

    Summary

    Official Symbol
    Ccl24provided by MGI
    Official Full Name
    C-C motif chemokine ligand 24provided by MGI
    Primary source
    MGI:MGI:1928953
    See related
    Ensembl:ENSMUSG00000004814 AllianceGenome:MGI:1928953
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CKb-6; MPIF-2; Scya24
    Summary
    Enables cytokine activity. Involved in positive regulation of angiogenesis and positive regulation of inflammatory response. Acts upstream of or within chemotaxis and positive regulation of eosinophil migration. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in asthma and rhinitis. Orthologous to human CCL24 (C-C motif chemokine ligand 24). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Broad expression in mammary gland adult (RPKM 5.0), liver E18 (RPKM 4.5) and 19 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Ccl24 in Genome Data Viewer
    Location:
    5 G2; 5 75.28 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (135598789..135601977, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (135569935..135573123, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene huntingtin interacting protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E434 Neighboring gene predicted gene, 52790 Neighboring gene C-C motif chemokine ligand 26 Neighboring gene STARR-seq mESC enhancer starr_14582 Neighboring gene STARR-positive B cell enhancer ABC_E9264 Neighboring gene STARR-seq mESC enhancer starr_14584 Neighboring gene STARR-seq mESC enhancer starr_14585 Neighboring gene rhomboid domain containing 2 Neighboring gene predicted gene 15607 Neighboring gene STARR-positive B cell enhancer ABC_E435 Neighboring gene predicted gene, 40345 Neighboring gene cytochrome p450 oxidoreductase

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (1)  1 citation

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables CCR chemokine receptor binding  
    enables CCR3 chemokine receptor binding  
    enables CCR3 chemokine receptor binding  
    enables chemokine activity  
    enables chemokine activity  
    enables chemokine activity  
    enables cytokine activity PubMed 
    enables receptor ligand activity  
    Process Evidence Code Pubs
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide  
    involved_in chemokine-mediated signaling pathway  
    acts_upstream_of_or_within chemotaxis PubMed 
    involved_in cytoskeleton organization  
    involved_in cytoskeleton organization  
    involved_in eosinophil chemotaxis  
    involved_in eosinophil chemotaxis  
    involved_in eosinophil chemotaxis  
    involved_in immune response  
    involved_in inflammatory response  
    involved_in inflammatory response  
    involved_in positive regulation of GTPase activity  
    involved_in positive regulation of actin filament polymerization  
    involved_in positive regulation of actin filament polymerization  
    involved_in positive regulation of angiogenesis PubMed 
    involved_in positive regulation of cell migration  
    involved_in positive regulation of cell migration  
    involved_in positive regulation of endothelial cell proliferation  
    involved_in positive regulation of endothelial cell proliferation  
    acts_upstream_of_or_within positive regulation of eosinophil migration PubMed 
    involved_in positive regulation of inflammatory response PubMed 
    involved_in regulation of cell shape  
    involved_in regulation of cell shape  
    involved_in signal transduction  
    Component Evidence Code Pubs
    is_active_in extracellular space  
    located_in extracellular space  

    General protein information

    Preferred Names
    C-C motif chemokine 24
    Names
    CC chemokine CCL24
    chemokine (C-C motif) ligand 24
    eosinophil chemotactic protein 2
    eotaxin-2
    small-inducible cytokine A24

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356630.1NP_001343559.1  C-C motif chemokine 24 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC083858, BC065389
      Consensus CDS
      CCDS19742.1
      UniProtKB/Swiss-Prot
      Q9JKC0
      UniProtKB/TrEMBL
      Q3U0A4
      Related
      ENSMUSP00000144002.2, ENSMUST00000201401.2
      Conserved Domains (1) summary
      cd00272
      Location:3390
      Chemokine_CC; 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; some members (e.g. 2HCC) contain an ...
    2. NM_019577.5NP_062523.1  C-C motif chemokine 24 precursor

      See identical proteins and their annotated locations for NP_062523.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC083858, AK009718, BC065389, BX524006
      Consensus CDS
      CCDS19742.1
      UniProtKB/Swiss-Prot
      Q9JKC0
      UniProtKB/TrEMBL
      Q3U0A4
      Related
      ENSMUSP00000004936.7, ENSMUST00000004936.10
      Conserved Domains (1) summary
      cd00272
      Location:3390
      Chemokine_CC; 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; some members (e.g. 2HCC) contain an ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      135598789..135601977 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006504444.3XP_006504507.1  C-C motif chemokine 24 isoform X1

      See identical proteins and their annotated locations for XP_006504507.1

      UniProtKB/Swiss-Prot
      Q9JKC0
      UniProtKB/TrEMBL
      Q3U0A4
      Conserved Domains (1) summary
      cd00272
      Location:3390
      Chemokine_CC; 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; some members (e.g. 2HCC) contain an ...
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