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    Yy1 YY1 transcription factor [ Mus musculus (house mouse) ]

    Gene ID: 22632, updated on 4-Jan-2025

    Summary

    Official Symbol
    Yy1provided by MGI
    Official Full Name
    YY1 transcription factorprovided by MGI
    Primary source
    MGI:MGI:99150
    See related
    Ensembl:ENSMUSG00000021264 AllianceGenome:MGI:99150
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    YY-1; NF-E1
    Summary
    Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in several processes, including DNA metabolic process; regulation of nucleobase-containing compound metabolic process; and response to UV-C. Acts upstream of or within with a positive effect on gene expression. Acts upstream of or within several processes, including anterior/posterior pattern specification; camera-type eye morphogenesis; and regulation of gene expression. Located in chromatin and nucleus. Part of PcG protein complex; chromatin silencing complex; and transcription regulator complex. Is expressed in several structures, including central nervous system; early conceptus; eye; hemolymphoid system gland; and reproductive system. Used to study pleuropulmonary blastoma. Human ortholog(s) of this gene implicated in congestive heart failure. Orthologous to human YY1 (YY1 transcription factor). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in ovary adult (RPKM 28.8), adrenal adult (RPKM 26.0) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Yy1 in Genome Data Viewer
    Location:
    12 F1; 12 59.58 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (108758841..108786074)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (108792945..108820148)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:110004036-110004330 Neighboring gene predicted gene, 33682 Neighboring gene predicted gene, 34220 Neighboring gene STARR-positive B cell enhancer ABC_E11524 Neighboring gene solute carrier family 25 (mitochondrial carrier, palmitoylcarnitine transporter), member 29 Neighboring gene STARR-positive B cell enhancer ABC_E7179 Neighboring gene predicted gene, 53767 Neighboring gene microRNA 345

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (5)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Items 1 - 25 of 26
    Function Evidence Code Pubs
    enables DNA binding PubMed 
    enables DNA binding PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific  
    enables DNA-binding transcription factor activity PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific  
    enables DNA-binding transcription factor binding  
    enables DNA-binding transcription factor binding  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific PubMed 
    enables RNA binding PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables SMAD binding  
    enables SMAD binding  
    enables chromatin binding PubMed 
    enables cis-regulatory region sequence-specific DNA binding  
    enables four-way junction DNA binding  
    enables four-way junction DNA binding  
    enables metal ion binding  
    enables protein binding PubMed 
    enables sequence-specific DNA binding PubMed 
    enables sequence-specific DNA binding  
    enables sequence-specific double-stranded DNA binding  
    enables transcription cis-regulatory region binding PubMed 
    Items 1 - 25 of 26
    Items 1 - 25 of 49
    Process Evidence Code Pubs
    involved_in B cell differentiation PubMed 
    involved_in DNA damage response PubMed 
    involved_in DNA damage response  
    acts_upstream_of_or_within RNA localization PubMed 
    acts_upstream_of_or_within anterior/posterior pattern specification PubMed 
    acts_upstream_of_or_within anterior/posterior pattern specification PubMed 
    acts_upstream_of_or_within camera-type eye morphogenesis PubMed 
    involved_in cellular response to UV  
    involved_in cellular response to UV  
    involved_in cellular response to interleukin-1  
    involved_in cellular response to interleukin-1  
    involved_in chromatin remodeling  
    involved_in chromosome organization PubMed 
    involved_in double-strand break repair via homologous recombination  
    involved_in double-strand break repair via homologous recombination  
    acts_upstream_of_or_within_positive_effect gene expression PubMed 
    involved_in hemopoiesis PubMed 
    involved_in immunoglobulin heavy chain V-D-J recombination PubMed 
    involved_in negative regulation of cell growth involved in cardiac muscle cell development  
    involved_in negative regulation of cell growth involved in cardiac muscle cell development  
    involved_in negative regulation of gene expression  
    involved_in negative regulation of interferon-beta production  
    involved_in negative regulation of interferon-beta production  
    involved_in negative regulation of miRNA transcription PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II PubMed 
    involved_in negative regulation of transcription by RNA polymerase II PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II PubMed 
    involved_in negative regulation of transcription by RNA polymerase II  
    involved_in positive regulation of DNA repair PubMed 
    involved_in positive regulation of DNA-templated transcription  
    acts_upstream_of_or_within positive regulation of gene expression PubMed 
    involved_in positive regulation of telomere maintenance in response to DNA damage PubMed 
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in regulation of DNA repair PubMed 
    involved_in regulation of DNA replication  
    involved_in regulation of DNA strand elongation  
    acts_upstream_of_or_within regulation of DNA-templated transcription PubMed 
    involved_in regulation of DNA-templated transcription  
    involved_in regulation of cell cycle  
    involved_in regulation of chromosome organization  
    involved_in regulation of embryonic development PubMed 
    involved_in regulation of transcription by RNA polymerase II  
    involved_in regulation of transcription by RNA polymerase II  
    involved_in response to UV-C PubMed 
    involved_in response to UV-C  
    involved_in response to prostaglandin F  
    involved_in spermatogenesis PubMed 
    involved_in telomere maintenance PubMed 
    Items 1 - 25 of 49
    Component Evidence Code Pubs
    part_of Ino80 complex  
    part_of PcG protein complex  
    part_of PcG protein complex PubMed 
    located_in chromatin  
    located_in chromatin PubMed 
    part_of chromatin silencing complex PubMed 
    located_in cytoplasm  
    located_in nuclear matrix  
    located_in nuclear matrix  
    located_in nucleoplasm  
    located_in nucleus PubMed 
    located_in nucleus  
    part_of transcription regulator complex  
    part_of transcription regulator complex PubMed 
    part_of transcription regulator complex  

    General protein information

    Preferred Names
    transcriptional repressor protein YY1
    Names
    UCR-motif DNA-binding protein
    UCRBP transcription factor
    Yin Yang 1
    delta transcription factor
    yin and yang 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009537.4NP_033563.2  transcriptional repressor protein YY1

      See identical proteins and their annotated locations for NP_033563.2

      Status: VALIDATED

      Source sequence(s)
      AA137984, AC152061, CX633032, M74590
      Consensus CDS
      CCDS26163.1
      UniProtKB/Swiss-Prot
      Q00899
      Related
      ENSMUSP00000021692.8, ENSMUST00000021692.9
      Conserved Domains (4) summary
      COG5048
      Location:268407
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:327347
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:325347
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:340365
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      108758841..108786074
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036157387.1XP_036013280.1  transcriptional repressor protein YY1 isoform X1

    RNA

    1. XR_004937493.1 RNA Sequence

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