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    Trip4 thyroid hormone receptor interactor 4 [ Mus musculus (house mouse) ]

    Gene ID: 56404, updated on 4-Jan-2025

    Summary

    Official Symbol
    Trip4provided by MGI
    Official Full Name
    thyroid hormone receptor interactor 4provided by MGI
    Primary source
    MGI:MGI:1928469
    See related
    Ensembl:ENSMUSG00000032386 AllianceGenome:MGI:1928469
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Asc1; ASC-1; 4930558E03Rik
    Summary
    Predicted to enable enzyme binding activity; nuclear estrogen receptor binding activity; and transcription coactivator activity. Involved in regulation of myoblast differentiation. Predicted to be located in cytoplasm; neuromuscular junction; and nuclear body. Predicted to be part of activating signal cointegrator 1 complex. Predicted to be active in nucleus. Predicted to colocalize with centrosome. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; retina nuclear layer; and skin. Orthologous to human TRIP4 (thyroid hormone receptor interactor 4). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in bladder adult (RPKM 5.1), testis adult (RPKM 4.6) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Trip4 in Genome Data Viewer
    Location:
    9 C; 9 35.55 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (65736208..65816150, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (65828926..65908875, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9768 Neighboring gene STARR-seq mESC enhancer starr_24469 Neighboring gene ornithine decarboxylase antizyme 2 Neighboring gene zinc finger protein 609 Neighboring gene STARR-seq mESC enhancer starr_24471 Neighboring gene ATP synthase subunit f, mitochondrial-like Neighboring gene ribosomal protein S2 pseudogene Neighboring gene predicted gene, 53535 Neighboring gene STARR-positive B cell enhancer ABC_E6756 Neighboring gene STARR-seq mESC enhancer starr_24473 Neighboring gene predicted gene, 23248 Neighboring gene PCNA clamp associated factor Neighboring gene casein kinase 1, gamma 1 Neighboring gene predicted gene, 22657 Neighboring gene STARR-positive B cell enhancer mm9_chr9:65852147-65852448 Neighboring gene sorting nexin 22 Neighboring gene peptidylprolyl isomerase B

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables histone acetyltransferase binding  
    enables histone acetyltransferase binding  
    enables nuclear estrogen receptor binding  
    enables nuclear estrogen receptor binding  
    enables nuclear receptor binding  
    enables nuclear receptor binding  
    enables protease binding  
    enables protease binding  
    enables protein kinase binding  
    enables protein kinase binding  
    enables transcription coactivator activity  
    enables transcription coactivator activity  
    enables ubiquitin-like protein ligase binding  
    enables ubiquitin-like protein ligase binding  
    enables zinc ion binding  
    Component Evidence Code Pubs
    part_of RQC-trigger complex  
    part_of activating signal cointegrator 1 complex  
    part_of activating signal cointegrator 1 complex  
    located_in centrosome  
    colocalizes_with centrosome  
    located_in cytoplasm  
    located_in cytosol  
    located_in neuromuscular junction  
    located_in neuromuscular junction  
    located_in nuclear body  
    located_in nuclear body  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus  
    located_in nucleus  
    part_of protein-containing complex  

    General protein information

    Preferred Names
    activating signal cointegrator 1
    Names
    TR-interacting protein 4
    TRIP-4
    thyroid receptor-interacting protein 4
    transcription coactivator Asc1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001170907.2NP_001164378.1  activating signal cointegrator 1 isoform 2

      See identical proteins and their annotated locations for NP_001164378.1

      Status: VALIDATED

      Source sequence(s)
      AC151906
      Consensus CDS
      CCDS52838.1
      UniProtKB/TrEMBL
      Q3UJV0
      Related
      ENSMUSP00000112866.2, ENSMUST00000122410.8
      Conserved Domains (2) summary
      cd06554
      Location:434525
      ASCH_ASC-1_like; ASC-1 homology domain, ASC-1-like subfamily. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain ...
      pfam06221
      Location:168216
      zf-C2HC5; Putative zinc finger motif, C2HC5-type
    2. NM_001357872.2NP_001344801.1  activating signal cointegrator 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC151906
      Consensus CDS
      CCDS23298.1
      UniProtKB/Swiss-Prot
      E9QK64, Q8CAD5, Q9QXN3
      UniProtKB/TrEMBL
      Q3UJV0
      Related
      ENSMUSP00000113949.2, ENSMUST00000117083.2
      Conserved Domains (2) summary
      cd06554
      Location:434547
      ASCH_ASC-1_like; ASC-1 homology domain, ASC-1-like subfamily. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain ...
      pfam06221
      Location:168216
      zf-C2HC5; Putative zinc finger motif, C2HC5-type
    3. NM_001433733.1NP_001420662.1  activating signal cointegrator 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC151906
      UniProtKB/Swiss-Prot
      E9QK64, Q8CAD5, Q9QXN3
      UniProtKB/TrEMBL
      Q3UJV0
    4. NM_001433734.1NP_001420663.1  activating signal cointegrator 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC151906
      UniProtKB/Swiss-Prot
      E9QK64, Q8CAD5, Q9QXN3
      UniProtKB/TrEMBL
      Q3UJV0
    5. NM_001433735.1NP_001420664.1  activating signal cointegrator 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC151906
      UniProtKB/TrEMBL
      Q3UJV0
    6. NM_001433736.1NP_001420665.1  activating signal cointegrator 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC151906
      UniProtKB/Swiss-Prot
      E9QK64, Q8CAD5, Q9QXN3
      UniProtKB/TrEMBL
      Q3UJV0
    7. NM_019797.5NP_062771.2  activating signal cointegrator 1 isoform 1

      See identical proteins and their annotated locations for NP_062771.2

      Status: VALIDATED

      Source sequence(s)
      AC151906
      Consensus CDS
      CCDS23298.1
      UniProtKB/Swiss-Prot
      E9QK64, Q8CAD5, Q9QXN3
      UniProtKB/TrEMBL
      Q3UJV0
      Related
      ENSMUSP00000112385.2, ENSMUST00000119245.8
      Conserved Domains (2) summary
      cd06554
      Location:434547
      ASCH_ASC-1_like; ASC-1 homology domain, ASC-1-like subfamily. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain ...
      pfam06221
      Location:168216
      zf-C2HC5; Putative zinc finger motif, C2HC5-type

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      65736208..65816150 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155144.1XP_036011037.1  activating signal cointegrator 1 isoform X2

      Related
      ENSMUSP00000137304.2, ENSMUST00000179395.8
      Conserved Domains (2) summary
      cd06554
      Location:434525
      ASCH_ASC-1_like; ASC-1 homology domain, ASC-1-like subfamily. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain ...
      pfam06221
      Location:168216
      zf-C2HC5; Putative zinc finger motif, C2HC5-type
    2. XM_006511298.5XP_006511361.1  activating signal cointegrator 1 isoform X1

      Conserved Domains (2) summary
      cd06554
      Location:434547
      ASCH_ASC-1_like; ASC-1 homology domain, ASC-1-like subfamily. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain ...
      pfam06221
      Location:168216
      zf-C2HC5; Putative zinc finger motif, C2HC5-type
    3. XM_030244463.2XP_030100323.1  activating signal cointegrator 1 isoform X1

      Conserved Domains (2) summary
      cd06554
      Location:434547
      ASCH_ASC-1_like; ASC-1 homology domain, ASC-1-like subfamily. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain ...
      pfam06221
      Location:168216
      zf-C2HC5; Putative zinc finger motif, C2HC5-type
    4. XM_036155143.1XP_036011036.1  activating signal cointegrator 1 isoform X2

      UniProtKB/TrEMBL
      Q3UJV0
      Conserved Domains (2) summary
      cd06554
      Location:434525
      ASCH_ASC-1_like; ASC-1 homology domain, ASC-1-like subfamily. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain ...
      pfam06221
      Location:168216
      zf-C2HC5; Putative zinc finger motif, C2HC5-type
    5. XM_036155146.1XP_036011039.1  activating signal cointegrator 1 isoform X3

      UniProtKB/TrEMBL
      Q3UBZ2
      Conserved Domains (1) summary
      pfam06221
      Location:168216
      zf-C2HC5; Putative zinc finger motif, C2HC5-type

    RNA

    1. XR_004935492.1 RNA Sequence

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