LRP1 LDL receptor related protein 1 [Gallus gallus (chicken)] - Gene

Summary

Symbol: LRP1provided by CGNC
Full Name: LDL receptor related protein 1provided by CGNC
Primary source: CGNC:49684
See related: Ensembl:ENSGALG00010025368
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: A2MR; LRP-1
Annotation information: Annotation category: suggests misassembly
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 34

Exon count:: 89

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	34	NC_052565.1 (1616096..1684420)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	34	NC_052606.1 (1323263..1344139, complement)

Chromosome 34 - NC_052565.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LRP1 regulates muscle fiber development in cooperation with related genes that affect myoblast proliferation and apoptosis, thereby impacting shear force in chickens.
Title: Low-density lipoprotein receptor-related protein 1 regulates muscle fiber development in cooperation with related genes to affect meat quality.
LRP1 exerts remarkable effects to retain the mature phenotype of chondrocytes as a critical mediator of cell signaling.
Title: Role of the low-density lipoprotein receptor-related protein-1 in regulation of chondrocyte differentiation.
LDL receptor and LDL receptor related protein 1 mRNA also tended to increase with follicular development.
Title: Modulation of sterol regulatory element binding protein-2 in response to rapid follicle development in chickens.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info	PubMed
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: low-density lipoprotein receptor-related protein 1

Names: alpha-2-macroglobulin receptor; low density lipoprotein receptor-related protein 1; prolow-density lipoprotein receptor-related protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_205242.3 → NP_990573.3 low-density lipoprotein receptor-related protein 1 precursor

Status: VALIDATED

Source sequence(s)

AM067712, BG713511, BI394825, BU206397, BU218845, BU227093, BU268976, BU369835, BU426443, BU427733, BU433463, BU436044, BU464648, BX540753, CT485966, DR431865, HAEK01196211, JAENSK010000490

UniProtKB/Swiss-Prot

P98157

Related

ENSGALP00010038280.1, ENSGALT00010061986.1

Conserved Domains (8) summary

smart00192
Location:3490 → 3523

LDLa; Low-density lipoprotein receptor domain class A

smart00135
Location:3091 → 3133

LY; Low-density lipoprotein-receptor YWTD domain

smart00179
Location:152 → 181

EGF_CA; Calcium-binding EGF-like domain

COG3386
Location:2244 → 2457

YvrE; Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]

cd00112
Location:3572 → 3606

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

cd05819
Location:3900 → 3947

NHL; NHL repeat [structural motif]

cl18310
Location:3868 → 4021

NHL; NHL repeat unit of beta-propeller proteins

cl00057
Location:2974 → 3016

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...