hbba1 hemoglobin, beta adult 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: hbba1provided by ZNC
Official Full Name: hemoglobin, beta adult 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-990415-18
See related: Ensembl:ENSDARG00000089087 AllianceGenome:ZFIN:ZDB-GENE-990415-18
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ba1; ba2; hbb; ba2l; hbba1.2; zgc:92900; zgc:123164; zgc:136512; si:dZ118J2.3; si:dz118j2.1; si:bY187G17.2
Summary: Predicted to enable heme binding activity; oxygen binding activity; and oxygen carrier activity. Predicted to contribute to haptoglobin binding activity and peroxidase activity. Acts upstream of or within response to hypoxia. Predicted to be part of haptoglobin-hemoglobin complex and hemoglobin complex. Is expressed in brain; eye; hematopoietic system; kidney; and vasculature. Human ortholog(s) of this gene implicated in sickle cell anemia. Orthologous to human HBE1 (hemoglobin subunit epsilon 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 3

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (55103441..55104355, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (54848843..54849708, complement)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Markers

hba1 (e-PCR)
- UniSTS:186966

U50380 (e-PCR)
- UniSTS:205677

fj04a05.x1 (e-PCR)
- UniSTS:198337

Clone Names

MGC63973, MGC73299, MGC92900, MGC123164, MGC136512

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
contributes_to haptoglobin binding	IBA Inferred from Biological aspect of Ancestor more info
enables heme binding	IBA Inferred from Biological aspect of Ancestor more info
enables heme binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxygen binding	IBA Inferred from Biological aspect of Ancestor more info
enables oxygen binding	IEA Inferred from Electronic Annotation more info
enables oxygen carrier activity	IBA Inferred from Biological aspect of Ancestor more info
enables oxygen carrier activity	IEA Inferred from Electronic Annotation more info
enables oxygen carrier activity	ISS Inferred from Sequence or Structural Similarity more info
contributes_to peroxidase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in hemopoiesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in hydrogen peroxide catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within oxygen transport	IEA Inferred from Electronic Annotation more info
involved_in oxygen transport	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within response to hypoxia	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of haptoglobin-hemoglobin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of hemoglobin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of hemoglobin complex	IEA Inferred from Electronic Annotation more info
part_of hemoglobin complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: hemoglobin subunit beta-1

Names: ba1 globin; ba2 globin; beta-1-globin; beta-2-globin; beta-A1-globin; beta-A2-globin; hemoglobin beta-1 chain; hemoglobin beta-2 chain; hemoglobin subunit beta-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.