fzd8b frizzled class receptor 8b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: fzd8bprovided by ZNC
Official Full Name: frizzled class receptor 8bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-000328-4
See related: Ensembl:ENSDARG00000038569 AllianceGenome:ZFIN:ZDB-GENE-000328-4
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fz6; fzA; ZG06; fz8b; zfzA; Zfz8b; ik:tdsubc_1e1; xx:tdsubc_1e1
Summary: Predicted to enable Wnt receptor activity and Wnt-protein binding activity. Acts upstream of or within dorsal/ventral pattern formation. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including forebrain; hypoblast; mesoderm; neural keel; and presumptive brain. Orthologous to human FZD8 (frizzled class receptor 8). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 2

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (47955160..47957670, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (48100996..48103506, complement)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables Wnt receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables Wnt-protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within dorsal/ventral pattern formation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within dorsal/ventral pattern formation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within dorsal/ventral pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in non-canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: frizzled-8b

Names: frizzled homolog 6; frizzled homolog 8b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131553.1 → NP_571628.1 frizzled-8b precursor

See identical proteins and their annotated locations for NP_571628.1

Status: PROVISIONAL

Source sequence(s)

AF060696

UniProtKB/TrEMBL

A0A2R8RRH4, Q6NWX8, Q9PWK6

Related

ENSDARP00000056304.3, ENSDART00000056305.5

Conserved Domains (2) summary

cd07461
Location:27 → 151

CRD_FZ8; Cysteine-rich Wnt-binding domain (CRD) of the frizzled 8 (Fz8) receptor

cd15250
Location:221 → 530

7tmF_FZD8; class F frizzled subfamily 8, member of 7-transmembrane G protein-coupled receptors