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    RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [ Gallus gallus (chicken) ]

    Gene ID: 395871, updated on 3-Dec-2024

    Summary

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    Symbol
    RAC1provided by CGNC
    Full Name
    ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)provided by CGNC
    Primary source
    CGNC:49523
    See related
    Ensembl:ENSGALG00010019145
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    CRAC1A
    Orthologs
    human mouse all
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    Genomic context

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    See RAC1 in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 14 NC_052545.1 (8829045..8842913, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 14 NC_052586.1 (8825962..8839830, complement)

    Chromosome 14 - NC_052545.1Genomic Context describing neighboring genes Neighboring gene KDEL endoplasmic reticulum protein retention receptor 2 Neighboring gene diacylglycerol lipase beta Neighboring gene cytohesin 3 Neighboring gene uncharacterized LOC124417201 Neighboring gene small integral membrane protein 10 like 1 Neighboring gene uncharacterized LOC121106843

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Rac1/p21-activated kinase pathway controls retinoblastoma protein phosphorylation and E2F transcription factor activation in B lymphocytes. Zaldua N, et al. FEBS J, 2016 Feb. PMID 26663827
    2. Lipid raft-targeted Akt promotes axonal branching and growth cone expansion via mTOR and Rac1, respectively. Grider MH, et al. J Neurosci Res, 2009 Nov 1. PMID 19530170, Free PMC Article
    3. Differential expression of distinct members of Rho family GTP-binding proteins during neuronal development: identification of Rac1B, a new neural-specific member of the family. Malosio ML, et al. J Neurosci, 1997 Sep 1. PMID 9254684, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. By evaluating the effect of Rac1, the RB-E2F complex activation dependency on PAK and PKCepsilon activities was established, being independent of both actin cytoskeleton reorganization and Ras activity.
      Title: Rac1/p21-activated kinase pathway controls retinoblastoma protein phosphorylation and E2F transcription factor activation in B lymphocytes.
    2. Akt activity can regulate growth cone expansion via localized Rac1 signaling and regulate axonal branching and soma size via activation of mTOR.
      Title: Lipid raft-targeted Akt promotes axonal branching and growth cone expansion via mTOR and Rac1, respectively.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin filament organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cortical cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in establishment or maintenance of cell polarity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in motor neuron axon guidance IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of cell shape IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in dendritic spine IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ras-related C3 botulinum toxin substrate 1
    Names
    GTPase cRac1A
    Rac family small GTPase 1
    NP_990348.1
    XP_015149624.1
    XP_046783248.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_205017.2 → NP_990348.1  ras-related C3 botulinum toxin substrate 1

      See identical proteins and their annotated locations for NP_990348.1

      Status: PROVISIONAL

      Source sequence(s)
      JAENSK010000257
      UniProtKB/TrEMBL
      A0A8V1AIF5, F1N8D9, Q6LC82
      Conserved Domains (1) summary
      cd01871
      Location:3 → 176
      Rac1_like; Ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)-like consists of Rac1, Rac2 and Rac3

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052545.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      8829045..8842913 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015294138.4 → XP_015149624.1  ras-related C3 botulinum toxin substrate 1 isoform X1

      UniProtKB/TrEMBL
      A0A8V0Z8U4, A0A8V1AIF5
      Related
      ENSGALP00010027595.1, ENSGALT00010046332.1
      Conserved Domains (1) summary
      cd01871
      Location:3 → 195
      Rac1_like; Ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)-like consists of Rac1, Rac2 and Rac3

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052586.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      8825962..8839830 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046927292.1 → XP_046783248.1  ras-related C3 botulinum toxin substrate 1 isoform X1

      UniProtKB/TrEMBL
      A0A8V0Z8U4, A0A8V1AIF5
    Nucleotide Protein
    Heading Accession and Version

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