tgm2b transglutaminase 2b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tgm2bprovided by ZNC
Official Full Name: transglutaminase 2bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-2576
See related: Ensembl:ENSDARG00000074094 AllianceGenome:ZFIN:ZDB-GENE-030131-2576
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: TGM2; fc12b04; wu:fc12b04; zgc:136700
Summary: Predicted to enable protein-glutamine gamma-glutamyltransferase activity. Predicted to be involved in phospholipase C-activating G protein-coupled receptor signaling pathway and positive regulation of apoptotic process. Predicted to act upstream of or within peptide cross-linking and proteolysis. Predicted to be located in several cellular components, including chromosome; cytosol; and extracellular region. Predicted to be active in mitochondrion. Is expressed in heart and notochord. Orthologous to human TGM2 (transglutaminase 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 6

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (2093390..2121803)
105	previous assembly	GRCz10 (GCF_000002035.5)	6	NC_007117.6 (1959724..1988137)

Chromosome 6 - NC_007117.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Transglutaminase Type 2 regulates the Wnt/beta-catenin pathway in vertebrates.
Title: Transglutaminase Type 2 regulates the Wnt/β-catenin pathway in vertebrates.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

fc12b04.y1 (e-PCR)
- UniSTS:192553

STS61.E4.1 (e-PCR)
- UniSTS:205488

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables protein-glutamine gamma-glutamyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-glutamine gamma-glutamyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein-glutamine glutaminase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within peptide cross-linking	IEA Inferred from Electronic Annotation more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: protein-glutamine gamma-glutamyltransferase 2

Names: transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)

NP_997821.2

EC 2.3.2.13

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_212656.2 → NP_997821.2 protein-glutamine gamma-glutamyltransferase 2

See identical proteins and their annotated locations for NP_997821.2

Status: PROVISIONAL

Source sequence(s)

BC117635

UniProtKB/TrEMBL

A0A8M1PHE7, F1R7N2, Q1ECX3

Related

ENSDARP00000099554.3, ENSDART00000114314.5

Conserved Domains (4) summary

smart00460
Location:260 → 353

TGc; Transglutaminase/protease-like homologues

COG1305
Location:254 → 361

YebA; Transglutaminase-like enzyme, putative cysteine protease [Posttranslational modification, protein turnover, chaperones]

pfam00868
Location:4 → 118

Transglut_N; Transglutaminase family

pfam00927
Location:579 → 679

Transglut_C; Transglutaminase family, C-terminal ig like domain