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    cyt1 type I cytokeratin, enveloping layer [ Danio rerio (zebrafish) ]

    Gene ID: 30327, updated on 4-Jan-2025

    Summary

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    Official Symbol
    cyt1provided by ZNC
    Official Full Name
    type I cytokeratin, enveloping layerprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-991008-6
    See related
    Ensembl:ENSDARG00000092947 AllianceGenome:ZFIN:ZDB-GENE-991008-6
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fa03a08; wu:fb34e10
    Summary
    Predicted to enable structural molecule activity. Acts upstream of or within cell migration involved in gastrulation. Predicted to be located in intermediate filament. Predicted to be active in cytoskeleton. Is expressed in EVL; embryonic structure; epidermis; epithelium; and periderm. Human ortholog(s) of this gene implicated in several diseases, including corneal dystrophy (multiple); ectodermal dysplasia (multiple); epidermolytic hyperkeratosis (multiple); focal nonepidermolytic palmoplantar keratoderma 1; and pachyonychia congenita. Orthologous to several human genes including KRT13 (keratin 13); KRT14 (keratin 14); and KRT15 (keratin 15). [provided by Alliance of Genome Resources, Jan 2025]
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    Genomic context

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    See cyt1 in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (5362564..5364596, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (5446078..5448110, complement)

    Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene keratin 92 Neighboring gene type I cytokeratin, enveloping layer, like Neighboring gene keratin 17 Neighboring gene keratin 91

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Type I keratin cDNAs from the rainbow trout: independent radiation of keratins in fish. Schaffeld M, et al. Differentiation, 2002 Aug. PMID 12190989
    2. Specification of the enveloping layer and lack of autoneuralization in zebrafish embryonic explants. Sagerström CG, et al. Dev Dyn, 2005 Jan. PMID 15543604
    3. Nontoxic chemical interdiction of the epithelial-to-mesenchymal transition by targeting cap-dependent translation. Ghosh B, et al. ACS Chem Biol, 2009 May 15. PMID 19351181, Free PMC Article
    4. Analysis of differentially expressed proteins in zebrafish (Danio rerio) embryos exposed to chlorpyrifos. Liu L, et al. Comp Biochem Physiol C Toxicol Pharmacol, 2015 Jan. PMID 25445019
    5. Cutaneous and Developmental Effects of CARD14 Overexpression in Zebrafish. Baniel A, et al. Biomedicines, 2022 Dec 8. PMID 36551948, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. neural specification in zebrafish requires cell contact or close cell proximity; outer cells express cyt1 by late blastula
      Title: Specification of the enveloping layer and lack of autoneuralization in zebrafish embryonic explants.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell migration involved in gastrulation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intermediate filament IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    type I cytokeratin, enveloping layer
    Names
    krtt1c19c

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131107.1 → NP_571182.1  type I cytokeratin, enveloping layer

      See identical proteins and their annotated locations for NP_571182.1

      Status: PROVISIONAL

      Source sequence(s)
      AF084461
      UniProtKB/TrEMBL
      A0A8M1PAJ8, Q9PWD8
      Related
      ENSDARP00000028148.8, ENSDART00000004812.10
      Conserved Domains (2) summary
      pfam00038
      Location:81 → 389
      Filament; Intermediate filament protein
      cl19730
      Location:234 → 383
      Wzz; Chain length determinant protein

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007130.7 Reference GRCz11 Primary Assembly

      Range
      5362564..5364596 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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