adh5 alcohol dehydrogenase 5 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: adh5provided by ZNC
Official Full Name: alcohol dehydrogenase 5provided by ZNC
Primary source: ZFIN:ZDB-GENE-011003-1
See related: Ensembl:ENSDARG00000080010 AllianceGenome:ZFIN:ZDB-GENE-011003-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ADH3; fb60b11; wu:fb60b11
Summary: Predicted to enable S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity; alcohol dehydrogenase (NAD+) activity; and zinc ion binding activity. Predicted to be involved in formaldehyde catabolic process. Predicted to be active in cytosol. Is expressed in several structures, including blastodisc; central nervous system; digestive system; pleuroperitoneal region; and trunk. Human ortholog(s) of this gene implicated in AMED syndrome and asthma. Orthologous to human ADH5 (alcohol dehydrogenase 5 (class III), chi polypeptide). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 14

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	14	NC_007125.7 (43590823..43602941, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	14	NC_007125.6 (43179150..43191268, complement)

Chromosome 14 - NC_007125.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Effects of the major formaldehyde catalyzer ADH5 on phenotypes of fanconi anemia zebrafish model.
Title: Effects of the major formaldehyde catalyzer ADH5 on phenotypes of fanconi anemia zebrafish model.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity	IBA Inferred from Biological aspect of Ancestor more info
enables S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity	IEA Inferred from Electronic Annotation more info
enables alcohol dehydrogenase (NAD+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in formaldehyde catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: alcohol dehydrogenase class-3

Names: gsnor

NP_571924.2

EC 1.1.1.284

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131849.2 → NP_571924.2 alcohol dehydrogenase class-3

See identical proteins and their annotated locations for NP_571924.2

Status: PROVISIONAL

Source sequence(s)

BC067170

UniProtKB/TrEMBL

A0A0R4IUR6, A0A8M1P9C8, Q6NXA6

Related

ENSDARP00000099464.2, ENSDART00000108825.5

Conserved Domains (2) summary

TIGR02818
Location:9 → 376

adh_III_F_hyde; S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase

cd08300
Location:8 → 374

alcohol_DH_class_III; class III alcohol dehydrogenases