SOCS3 suppressor of cytokine signaling 3 [Gallus gallus (chicken)] - Gene

Summary

Symbol: SOCS3provided by CGNC
Full Name: suppressor of cytokine signaling 3provided by CGNC
Primary source: CGNC:66201
See related: Ensembl:ENSGALG00010029295
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 18

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	18	NC_052549.1 (10472830..10474859)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	18	NC_052590.1 (10073162..10075189)

Chromosome 18 - NC_052549.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Taken together, these data demonstrate that Newcastle disease virus infection and Newcastle disease virus nonstructural V protein activates the expression of SOCS3 at the mRNA and protein level through a mechanism dependent on the MEK/ERK signaling pathway, which benefits virus replication.
Title: Newcastle Disease Virus Nonstructural V Protein Upregulates SOCS3 Expression to Facilitate Viral Replication Depending on the MEK/ERK Pathway.
highlight the crucial role of gga-miR-455-5p in host defense against NDV by targeting the SOCS3 gene to inhibit Newcastle disease virus replication
Title: MicroRNA gga-miR-455-5p suppresses Newcastle disease virus replication via targeting cellular suppressors of cytokine signaling 3.
It is a gene related to signal transduction.
Title: Effect of chicken leptin recptor short hairpin RNA on expression of JAK2, STAT3, SOCS3 and CPT1 genes in chicken preadipocytes.
these results inferred that SOCS3 promotes adipocyte apoptosis by both aggravating inflammation and inhibiting the activity of JAK2/STAT3 signaling pathway.
Title: SOCS3 promotes inflammation and apoptosis via inhibiting JAK2/STAT3 signaling pathway in 3T3-L1 adipocyte.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables 1-phosphatidylinositol-3-kinase regulator activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info	PubMed
involved_in phosphatidylinositol phosphate biosynthetic process	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
part_of phosphatidylinositol 3-kinase complex	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: suppressor of cytokine signaling 3

Names: SOCS-3; suppressors of cytokine signaling 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_204600.2 → NP_989931.2 suppressor of cytokine signaling 3

Status: PROVISIONAL

Source sequence(s)

JAENSK010000317

UniProtKB/Swiss-Prot

Q90X67

UniProtKB/TrEMBL

B6RCQ3, R4GJH9

Related

ENSGALP00010043537.1, ENSGALT00010070846.1

Conserved Domains (2) summary

cd10384
Location:35 → 135

SH2_SOCS3; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins

cd03737
Location:168 → 209

SOCS_SOCS3; SOCS (suppressors of cytokine signaling) box of SOCS3-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS3, like CIS1 and SOCS1, is involved in the ...