jag1a jagged canonical Notch ligand 1a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: jag1aprovided by ZNC
Official Full Name: jagged canonical Notch ligand 1aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-011128-2
See related: Ensembl:ENSDARG00000030289 AllianceGenome:ZFIN:ZDB-GENE-011128-2
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: jag1; cb243; sb:cb243; serrateC
Summary: Predicted to enable Notch binding activity. Involved in positive regulation of hematopoietic stem cell differentiation. Acts upstream of or within several processes, including hematopoietic stem cell differentiation; regulation of non-canonical NF-kappaB signal transduction; and thyroid gland development. Is active in plasma membrane. Is expressed in several structures, including digestive system; lens placode; nervous system; neural keel; and neural tube. Human ortholog(s) of this gene implicated in Alagille syndrome; Charcot-Marie-Tooth disease; congenital heart disease; multiple sclerosis; and tetralogy of Fallot. Orthologous to human JAG1 (jagged canonical Notch ligand 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 1

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (51104984..51157675, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	1	NC_007112.6 (50461185..50513890, complement)

Chromosome 1 - NC_007112.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Delta/Jagged-mediated Notch signaling induces the differentiation of agr2-positive epidermal mucous cells in zebrafish embryos.
Title: Delta/Jagged-mediated Notch signaling induces the differentiation of agr2-positive epidermal mucous cells in zebrafish embryos.
Multiple myeloma exploits Jagged1 and Jagged2 to promote intrinsic and bone marrow-dependent drug resistance.
Title: Multiple myeloma exploits Jagged1 and Jagged2 to promote intrinsic and bone marrow-dependent drug resistance.
Notch pathway is involved in the early steps of thyroid morphogenesis, and Jagged1-Notch signal is required for zebrafish thyroid development and function
Title: Disruptions of global and JAGGED1-mediated notch signaling affect thyroid morphogenesis in the zebrafish.
Mib-Jag1-Notch signalling regulates patterning and structural roles of the notochord by controlling cell-fate decisions
Title: Mib-Jag1-Notch signalling regulates patterning and structural roles of the notochord by controlling cell-fate decisions.
Jagged and Delta ligands are functionally redundant or required in specific combinations in many differentiation processes
Title: Expression analysis of jagged genes in zebrafish embryos.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables Notch binding	IBA Inferred from Biological aspect of Ancestor more info
enables Notch binding	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables receptor ligand activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within Notch signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within Notch signaling pathway	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in animal organ development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell communication	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within hematopoietic stem cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within hematopoietic stem cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hepaticobiliary system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of hematopoietic stem cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of non-canonical NF-kappaB signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in system development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within thyroid gland development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within thyroid gland development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	NAS Non-traceable Author Statement more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: protein jagged-1a

Names: jagged 1a; jagged1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131861.1 → NP_571936.1 protein jagged-1a precursor

See identical proteins and their annotated locations for NP_571936.1

Status: PROVISIONAL

Source sequence(s)

AF229448

UniProtKB/Swiss-Prot

Q90Y57

Related

ENSDARP00000047850.7, ENSDART00000047851.7

Conserved Domains (5) summary

smart00215
Location:866 → 934

VWC_out; von Willebrand factor (vWF) type C domain

cd00054
Location:488 → 524

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam00008
Location:751 → 781

EGF; EGF-like domain

pfam01414
Location:168 → 230

DSL; Delta serrate ligand

pfam07657
Location:29 → 103

MNNL; N terminus of Notch ligand

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007112.7 Reference GRCz11 Primary Assembly

Range

51104984..51157675 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005168205.5 → XP_005168262.1 protein jagged-1a isoform X2

UniProtKB/TrEMBL

A0A8M2BFK4

Conserved Domains (5) summary

smart00215
Location:866 → 934

VWC_out; von Willebrand factor (vWF) type C domain

cd00054
Location:488 → 524

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam00008
Location:751 → 781

EGF; EGF-like domain

pfam01414
Location:168 → 230

DSL; Delta serrate ligand

pfam07657
Location:29 → 103

MNNL; N terminus of Notch ligand
XM_005168204.5 → XP_005168261.1 protein jagged-1a isoform X1

UniProtKB/TrEMBL

A0A8M2BFJ9, B8JKQ5

Related

ENSDARP00000121170.1, ENSDART00000137172.3

Conserved Domains (5) summary

smart00215
Location:866 → 934

VWC_out; von Willebrand factor (vWF) type C domain

cd00054
Location:488 → 524

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam00008
Location:751 → 781

EGF; EGF-like domain

pfam01414
Location:168 → 230

DSL; Delta serrate ligand

pfam07657
Location:29 → 103

MNNL; N terminus of Notch ligand