pou3f2a POU class 3 homeobox 2a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: pou3f2aprovided by ZNC
Official Full Name: POU class 3 homeobox 2aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-980526-139
See related: Ensembl:ENSDARG00000070220 AllianceGenome:ZFIN:ZDB-GENE-980526-139
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: brn1.2; brn-1.2; id:ibd5088
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within brain development and regulation of DNA-templated transcription. Predicted to be located in nucleus. Is expressed in brain; neural keel; neural plate; and spinal cord. Orthologous to human POU3F2 (POU class 3 homeobox 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 4

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	4	NC_007115.7 (5741795..5744465)
105	previous assembly	GRCz10 (GCF_000002035.5)	4	NC_007115.6 (5733225..5735895)

Chromosome 4 - NC_007115.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

Pou3f1 (e-PCR), detects polymorphism
- UniSTS:530696

brn1.2 (e-PCR), detects polymorphism
- UniSTS:186936

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within brain development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: POU domain, class 3, transcription factor 2a

Names: brain POU domain gene 1.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131289.1 → NP_571364.1 POU domain, class 3, transcription factor 2a

See identical proteins and their annotated locations for NP_571364.1

Status: PROVISIONAL

Source sequence(s)

BC129152

UniProtKB/TrEMBL

A0A8M1P7H1, A2VD21

Related

ENSDARP00000103478.2, ENSDART00000110243.4

Conserved Domains (2) summary

smart00352
Location:159 → 233

POU; Found in Pit-Oct-Unc transcription factors

pfam00046
Location:254 → 307

Homeobox; Homeobox domain