isl2b ISL LIM homeobox 2b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: isl2bprovided by ZNC
Official Full Name: ISL LIM homeobox 2bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-990415-133
See related: Ensembl:ENSDARG00000053499 AllianceGenome:ZFIN:ZDB-GENE-990415-133
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: isl3; ISL-3; islet 3; zfIsl-3; zgc:109840
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within exocrine pancreas development and secondary heart field specification. Predicted to be active in nucleus. Is expressed in several structures, including alar plate midbrain region; anterior lateral plate mesoderm; nervous system; pancreas; and trigeminal placode. Orthologous to human ISL2 (ISL LIM homeobox 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 7

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (29992889..29996894)
105	previous assembly	GRCz10 (GCF_000002035.5)	7	NC_007118.6 (29721739..29725744)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Isl2b regulates anterior second heart field development in zebrafish.
Title: Retooling Laser Speckle Contrast Analysis Algorithm to Enhance Non-Invasive High Resolution Laser Speckle Functional Imaging of Cutaneous Microcirculation.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in axonogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within exocrine pancreas development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in neuron fate specification	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neuron fate specification	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within secondary heart field specification	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: insulin gene enhancer protein isl-2b

Names: insulin gene enhancer protein isl-3; islet-2B; islet-3; islet2b; islet3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_130964.2 → NP_571039.1 insulin gene enhancer protein isl-2b

See identical proteins and their annotated locations for NP_571039.1

Status: PROVISIONAL

Source sequence(s)

BC095011

UniProtKB/Swiss-Prot

P53407, Q504I1, Q6LD05

Related

ENSDARP00000055935.3, ENSDART00000055936.5

Conserved Domains (3) summary

cd09366
Location:27 → 81

LIM1_Isl; The first LIM domain of Isl, a member of LHX protein family

cd09471
Location:89 → 143

LIM2_Isl2; The second LIM domain of Isl2

smart00389
Location:191 → 247

HOX; Homeodomain