U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    tpm4.S tropomyosin 4 S homeolog [ Xenopus laevis (African clawed frog) ]

    Gene ID: 379628, updated on 4-Jan-2025

    Summary

    Go to the top of the page Help
    Official Symbol
    tpm4.S
    Official Full Name
    tropomyosin 4 S homeolog
    Primary source
    Xenbase:XB-GENE-6255195
    Locus tag
    XELAEV_18009894mg
    See related
    EnsemblRapid:ENSXLAG00005014524 AllianceGenome:Xenbase:XB-GENE-6255195
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Xenopus laevis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
    Also known as
    tm4; tm-4; tpm4; tpm4-a; tpm4-b; tpm4.L
    Summary
    Predicted to enable actin binding activity and metal ion binding activity. Predicted to be located in cytoskeleton. Human ortholog(s) of this gene implicated in blood platelet disease. Orthologous to human TPM4 (tropomyosin 4). [provided by Alliance of Genome Resources, Jan 2025]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See tpm4.S in Genome Data Viewer
    Location:
    chromosome: 1S
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 1S NC_054372.1 (95128407..95199615)
    100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 1S NC_030725.1 (89894581..89922165)

    Chromosome 1S - NC_054372.1Genomic Context describing neighboring genes Neighboring gene granzyme H S homeolog Neighboring gene hematopoietic SH2 domain-containing protein Neighboring gene uncharacterized LOC121399375 Neighboring gene RAB8A, member RAS oncogene family S homeolog Neighboring gene pinhead S homeolog

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The Xenopus laevis TM-4 gene encodes non-muscle and cardiac tropomyosin isoforms through alternative splicing. Hardy S, et al. Gene, 1995 Apr 24. PMID 7758966
    2. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Homology

    Clone Names

    • MGC68438

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    tropomyosin 4 S homeolog
    Names
    non-muscle tropomyosin
    tropomyosin 4 L homeolog

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001086468.1 → NP_001079937.1  tropomyosin 4 S homeolog

      See identical proteins and their annotated locations for NP_001079937.1

      Status: PROVISIONAL

      Source sequence(s)
      BC057705
      UniProtKB/TrEMBL
      A0A974DUG6, Q6PF72, Q91865
      Conserved Domains (1) summary
      pfam00261
      Location:12 → 245
      Tropomyosin

    RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Xenopus_laevis_v10.1 Primary Assembly

    Genomic

    1. NC_054372.1 Reference Xenopus_laevis_v10.1 Primary Assembly

      Range
      95128407..95199615
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_041572926.1 → XP_041428860.1  tropomyosin 4 S homeolog isoform X3

      UniProtKB/TrEMBL
      A0A1L8HNK0, A0A974DT48, Q91726
      Related
      ENSXLAP00005042501.1, ENSXLAT00005043568.1
      Conserved Domains (1) summary
      pfam00261
      Location:48 → 282
      Tropomyosin

    2. XM_041572921.1 → XP_041428855.1  tropomyosin 4 S homeolog isoform X1

      UniProtKB/TrEMBL
      A0A8J1LJI8
      Conserved Domains (1) summary
      TIGR02168
      Location:11 → 264
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    3. XM_018233150.2 → XP_018088639.1  tropomyosin 4 S homeolog isoform X2

      UniProtKB/TrEMBL
      A0A974DUG6, Q6PF72, Q91865
      Conserved Domains (1) summary
      pfam00261
      Location:12 → 245
      Tropomyosin
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.