atp1a2a ATPase Na+/K+ transporting subunit alpha 2a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: atp1a2aprovided by ZNC
Official Full Name: ATPase Na+/K+ transporting subunit alpha 2aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-001212-6
See related: Ensembl:ENSDARG00000010472 AllianceGenome:ZFIN:ZDB-GENE-001212-6
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: atpa2; cb702; atp1a2; atp[a]2; fa10d04; fa10d05; wu:fa10d05
Summary: Predicted to enable P-type sodium:potassium-exchanging transporter activity. Acts upstream of or within several processes, including heart looping; specification of animal organ axis polarity; and thigmotaxis. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including Kupffer's vesicle; brain; musculature system; pharyngeal arch 3-7 skeleton; and pronephric duct. Human ortholog(s) of this gene implicated in alternating hemiplegia of childhood; electroclinical syndrome (multiple); hypertension; and migraine with aura (multiple). Orthologous to human ATP1A2 (ATPase Na+/K+ transporting subunit alpha 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 2

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (44203078..44255537, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (44350080..44402539, complement)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Na,K-ATPase alpha2 and Ncx4a regulate left-right patterning by modulating intracellular calcium levels in Kupffer's vesicle and by influencing cilia function
Title: Na,K-ATPase alpha2 and Ncx4a regulate zebrafish left-right patterning.

Submit: New GeneRIF Correction

General gene information

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Markers

fa10d05.s1 (e-PCR)
- UniSTS:202280

fb19d03.y1 (e-PCR)
- UniSTS:190256

aa494579 (e-PCR)
- UniSTS:186787

aa494679 (e-PCR)
- UniSTS:186795

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables P-type potassium transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables P-type sodium:potassium-exchanging transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within determination of heart left/right asymmetry	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within determination of left/right symmetry	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within determination of left/right symmetry	IMP Inferred from Mutant Phenotype more info	PubMed
NOT acts_upstream_of_or_within embryonic heart tube development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within fluid transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart contraction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart looping	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular potassium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular sodium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in potassium ion import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within potassium ion transport	IEA Inferred from Electronic Annotation more info
involved_in proton transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of cytosolic calcium ion concentration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within skeletal muscle tissue development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sodium ion export across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within sodium ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within specification of animal organ axis polarity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within thigmotaxis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: sodium/potassium-transporting ATPase subunit alpha-2

Names: ATPase Na+/K+ transporting subunit alpha 2; ATPase, Na+/K+ transporting, alpha 2 polypeptide; ATPase, Na+/K+ transporting, alpha 2a polypeptide

NP_571758.1

EC 7.2.2.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131683.1 → NP_571758.1 sodium/potassium-transporting ATPase subunit alpha-2

See identical proteins and their annotated locations for NP_571758.1

Status: PROVISIONAL

Source sequence(s)

AF286373

UniProtKB/TrEMBL

Q9DGL5

Related

ENSDARP00000024272.7, ENSDART00000011188.9

Conserved Domains (6) summary

smart00831
Location:35 → 109

Cation_ATPase_N; Cation transporter/ATPase, N-terminus

COG4087
Location:600 → 746

COG4087; Soluble P-type ATPase [General function prediction only]

TIGR01106
Location:34 → 1017

ATPase-IIC_X-K; sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit

pfam00122
Location:129 → 360

E1-E2_ATPase; E1-E2 ATPase

pfam00689
Location:793 → 1002

Cation_ATPase_C; Cation transporting ATPase, C-terminus

pfam13246
Location:422 → 515

Cation_ATPase; Cation transport ATPase (P-type)