exo1.S exonuclease 1 S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: exo1.S
Official Full Name: exonuclease 1 S homeolog
Primary source: Xenbase:XB-GENE-982081
Locus tag: XELAEV_18042391mg
See related: EnsemblRapid:ENSXLAG00005010095 AllianceGenome:Xenbase:XB-GENE-982081
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: exo1; exoi; Xexo1
Summary: Predicted to enable flap endonuclease activity and single-stranded DNA 5'-3' DNA exonuclease activity. Predicted to act upstream of or within DNA recombination and mismatch repair. Predicted to be located in nucleus. Orthologous to human EXO1 (exonuclease 1). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

Location:: chromosome: 8S

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	8S	NC_054386.1 (79869653..79890654, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	8S	NC_030739.1 (77487234..77508245, complement)

Chromosome 8S - NC_054386.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables 5'-3' DNA exonuclease activity	IEA Inferred from Electronic Annotation more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables endonuclease activity	IEA Inferred from Electronic Annotation more info
enables exonuclease activity	IEA Inferred from Electronic Annotation more info
enables flap endonuclease activity	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables single-stranded DNA 5'-3' DNA exonuclease activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA recombination	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within DNA repair	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mismatch repair	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: exonuclease 1

Names: exonuclease ExoI; exonuclease I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001090358.1 → NP_001083827.1 exonuclease 1

See identical proteins and their annotated locations for NP_001083827.1

Status: PROVISIONAL

Source sequence(s)

BC084102

UniProtKB/Swiss-Prot

Q5XHF5, Q9W6K2

UniProtKB/TrEMBL

A0A974H6F8

Related

ENSXLAP00005029789.1, ENSXLAT00005030539.1

Conserved Domains (4) summary

cd09908
Location:213 → 289

H3TH_EXO1; H3TH domain of Exonuclease-1, a structure-specific, divalent-metal-ion dependent, 5' nuclease

cd09857
Location:1 → 206

PIN_EXO1; PIN domain of Exonuclease-1, a structure-specific, divalent-metal-ion dependent, 5' nuclease and homologs

TIGR03674
Location:1 → 313

fen_arch; flap structure-specific endonuclease

pfam12590
Location:651 → 700

Acyl-thio_N; Acyl-ATP thioesterase

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054386.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

79869653..79890654 complement

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GenBank, FASTA, Sequence Viewer (Graphics)