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    YPEL4 yippee like 4 [ Homo sapiens (human) ]

    Gene ID: 219539, updated on 10-Dec-2024

    Summary

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    Official Symbol
    YPEL4provided by HGNC
    Official Full Name
    yippee like 4provided by HGNC
    Primary source
    HGNC:HGNC:18328
    See related
    Ensembl:ENSG00000166793 MIM:609725; AllianceGenome:HGNC:18328
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable metal ion binding activity. Predicted to act upstream of or within several processes, including negative regulation of erythrocyte clearance; negative regulation of erythrocyte differentiation; and protein localization to plasma membrane. Predicted to be located in nucleolus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in brain (RPKM 4.8), bone marrow (RPKM 3.2) and 12 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See YPEL4 in Genome Data Viewer
    Location:
    11q12.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (57645087..57649912, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (57595261..57603883, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (57412560..57417385, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene serpin family G member 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3352 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3353 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:57406889-57407468 Neighboring gene MIR130A host gene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:57410743-57411242 Neighboring gene microRNA 130a Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4725 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4726 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3354 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4727 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:57435387-57436026 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:57436027-57436664 Neighboring gene cleavage factor polyribonucleotide kinase subunit 1 Neighboring gene zinc finger DHHC-type palmitoyltransferase 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. YPEL4 modulates HAC15 adrenal cell proliferation and is associated with tumor diameter. Oki K, et al. Mol Cell Endocrinol, 2016 Oct 15. PMID 27333825, Free PMC Article
    2. MVP interacts with YPEL4 and inhibits YPEL4-mediated activities of the ERK signal pathway. Liang P, et al. Biochem Cell Biol, 2010 Jun. PMID 20555386
    3. Identification and characterization of a novel gene family YPEL in a wide spectrum of eukaryotic species. Hosono K, et al. Gene, 2004 Sep 29. PMID 15556292
    4. Centrosome-related genes, genetic variation, and risk of breast cancer. Olson JE, et al. Breast Cancer Res Treat, 2011 Jan. PMID 20508983, Free PMC Article
    5. Biological insights from 108 schizophrenia-associated genetic loci. Schizophrenia Working Group of the Psychiatric Genomics Consortium. Nature, 2014 Jul 24. PMID 25056061, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results demonstrated that YPEL4 stimulates human adrenal cortical cell proliferation, increasing aldosterone production. Also, YPEL4 expression levels are higher in human aldosterone producing adenoma.
      Title: YPEL4 modulates HAC15 adrenal cell proliferation and is associated with tumor diameter.
    2. Data show that major vault protein (MVP), a lung resistance associated protein, is a binding partner of YPEL4.
      Title: MVP interacts with YPEL4 and inhibits YPEL4-mediated activities of the ERK signal pathway.
    3. Observational study of gene-disease association. (HuGE Navigator)
      Title: Centrosome-related genes, genetic variation, and risk of breast cancer.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Biological insights from 108 schizophrenia-associated genetic loci.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ30213, MGC102723, MGC138324

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein yippee-like 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001363487.2 → NP_001350416.1  protein yippee-like 4

      Status: VALIDATED

      Source sequence(s)
      AP000662
      Consensus CDS
      CCDS7963.1
      UniProtKB/Swiss-Prot
      B3KW92, Q2M3U7, Q65Z98, Q96NS1
      UniProtKB/TrEMBL
      B3KNT4
      Conserved Domains (1) summary
      cl13152
      Location:28 → 118
      RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains

    2. NM_145008.3 → NP_659445.1  protein yippee-like 4

      See identical proteins and their annotated locations for NP_659445.1

      Status: VALIDATED

      Source sequence(s)
      AB098738
      Consensus CDS
      CCDS7963.1
      UniProtKB/Swiss-Prot
      B3KW92, Q2M3U7, Q65Z98, Q96NS1
      UniProtKB/TrEMBL
      B3KNT4
      Related
      ENSP00000300022.3, ENST00000300022.8
      Conserved Domains (1) summary
      cl13152
      Location:28 → 118
      RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      57645087..57649912 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047426531.1 → XP_047282487.1  protein yippee-like 4 isoform X1

      UniProtKB/Swiss-Prot
      B3KW92, Q2M3U7, Q65Z98, Q96NS1
      UniProtKB/TrEMBL
      B3KNT4
      Related
      ENSP00000432648.1, ENST00000524669.5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      57595261..57603883 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054367978.1 → XP_054223953.1  protein yippee-like 4 isoform X1

      UniProtKB/Swiss-Prot
      B3KW92, Q2M3U7, Q65Z98, Q96NS1
      UniProtKB/TrEMBL
      B3KNT4

    2. XM_054367977.1 → XP_054223952.1  protein yippee-like 4 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96NS1.1 GenPept UniProtKB/Swiss-Prot:Q96NS1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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