ARL4C ARF like GTPase 4C [Homo sapiens (human)] - Gene

Summary

Official Symbol: ARL4Cprovided by HGNC
Official Full Name: ARF like GTPase 4Cprovided by HGNC
Primary source: HGNC:HGNC:698
See related: Ensembl:ENSG00000188042 MIM:604787; AllianceGenome:HGNC:698
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: LAK; ARL7
Summary: ADP-ribosylation factor-like 4C is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL4C is closely similar to ARL4A and ARL4D and each has a nuclear localization signal and an unusually high guanine nucleotide exchange rate. This protein may play a role in cholesterol transport. [provided by RefSeq, Jul 2008]
Expression: Broad expression in lymph node (RPKM 30.2), spleen (RPKM 30.0) and 20 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 2q37.1

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	2	NC_000002.12 (234493041..234497081, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	2	NC_060926.1 (234982177..234986217, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (235401685..235405725, complement)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Stepwise activation of p63 and the MEK/ERK pathway induces the expression of ARL4C to promote oral squamous cell carcinoma cell proliferation.
Title: Stepwise activation of p63 and the MEK/ERK pathway induces the expression of ARL4C to promote oral squamous cell carcinoma cell proliferation.
ARL4C is associated with epithelial-to-mesenchymal transition in colorectal cancer.
Title: ARL4C is associated with epithelial-to-mesenchymal transition in colorectal cancer.
ARL4C depletion suppresses the resistance of ovarian cancer to carboplatin by disrupting cholesterol transport and autophagy via notch-RBP-Jkappa-H3K4Me3-OSBPL5.
Title: ARL4C depletion suppresses the resistance of ovarian cancer to carboplatin by disrupting cholesterol transport and autophagy via notch-RBP-Jκ-H3K4Me3-OSBPL5.
Identification of Neural Progenitor Cell-associated Chemoradiotherapy Resistance Gene Set (ARL4C, MSN, TNFAIP6) for Prognosis of Glioma.
Title: Identification of Neural Progenitor Cell-associated Chemoradiotherapy Resistance Gene Set (ARL4C, MSN, TNFAIP6) for Prognosis of Glioma.
RAF1-MEK/ERK pathway-dependent ARL4C expression promotes ameloblastoma cell proliferation and osteoclast formation.
Title: RAF1-MEK/ERK pathway-dependent ARL4C expression promotes ameloblastoma cell proliferation and osteoclast formation.
ARL4C might serve as a prognostic factor and a novel therapeutic target for gastric cancer: bioinformatics analyses and biological experiments.
Title: ARL4C might serve as a prognostic factor and a novel therapeutic target for gastric cancer: bioinformatics analyses and biological experiments.
High ARL4C expression is associated with Peritoneal Dissemination in Gastric Cancer.
Title: ASO Author Reflections: ARL4C and Peritoneal Dissemination in Gastric Cancer.
ARL4C is involved in the initiation of the premalignant stage.
Title: ARL4C is associated with initiation and progression of lung adenocarcinoma and represents a therapeutic target.
ARL4C antisense oligonucleotides (ASO) accumulated in cancer cells more efficiently than the surrounding normal cells in the liver and decreased ARL4C expression in the tumor. These results suggest that ARL4C ASO represents a novel targeted nucleic acid medicine for the treatment of primary and metastatic liver cancers.
Title: Chemically Modified Antisense Oligonucleotide Against ARL4C Inhibits Primary and Metastatic Liver Tumor Growth.
ARL4C stabilized by AKT/mTOR pathway promotes the invasiveness of PTEN-deficient glioblastoma cells.
Title: ARL4C stabilized by AKT/mTOR pathway promotes the invasion of PTEN-deficient primary human glioblastoma.

Submit: New GeneRIF Correction See all GeneRIFs (20)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study identifies 8 novel loci associated with blood pressure responses to interventions in Han Chinese. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study of pancreatic cancer in Japanese population. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS-T91940 (e-PCR)
- UniSTS:24336

D2S1923 (e-PCR)
- UniSTS:153687

WI-15413 (e-PCR)
- UniSTS:48077

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables alpha-tubulin binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in endocytic recycling	IBA Inferred from Biological aspect of Ancestor more info
involved_in endocytic recycling	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info
located_in filopodium	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HTP more info	PubMed
located_in nucleus	TAS Traceable Author Statement more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: ADP-ribosylation factor-like protein 4C

Names: ADP ribosylation factor like GTPase 4C; ADP ribosylation factor-like protein 7; ADP-ribosylation factor-like 4C; ADP-ribosylation factor-like 7; ADP-ribosylation factor-like protein LAK

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001282431.2 → NP_001269360.1 ADP-ribosylation factor-like protein 4C isoform 1

See identical proteins and their annotated locations for NP_001269360.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1)

Source sequence(s)

AC105145, AJ579850, BC089043

Consensus CDS

CCDS63169.1

UniProtKB/Swiss-Prot

P56559

Related

ENSP00000339754.3, ENST00000339728.6

Conserved Domains (1) summary

cd04152
Location:11 → 192

Arl4_Arl7; Arf-like 4 (Arl4) and 7 (Arl7) GTPases
NM_005737.3 → NP_005728.2 ADP-ribosylation factor-like protein 4C isoform 2

See identical proteins and their annotated locations for NP_005728.2

Status: REVIEWED

Description

Transcript Variant: This variant (2) contains an additional internal segment which results in alternate stop codon compared to variant 1. The encoded isoform (2) has a shorter C-terminus compared to isoform 1.

Source sequence(s)

BC001051, BM541491, BM904613, BU844902, CA413100, CD358707, Y17804

Consensus CDS

CCDS2512.1

UniProtKB/Swiss-Prot

P56559, Q4A519, Q53R10, Q9BVN1, Q9UQ34

Related

ENSP00000375057.2, ENST00000390645.2

Conserved Domains (1) summary

cd04152
Location:11 → 192

Arl4_Arl7; Arf-like 4 (Arl4) and 7 (Arl7) GTPases